CHRNA2

Cholinergic receptor, nicotinic, alpha 2 (neuronal)
Identifiers
Symbol	CHRNA2
External IDs	OMIM: 118502 MGI: 87886 HomoloGene: 20193 IUPHAR: 463 ChEMBL: 1794 GeneCards: CHRNA2 Gene
Gene ontology Molecular function • acetylcholine-activated cation-selective channel activity • drug binding • acetylcholine receptor activity • acetylcholine binding Cellular component • plasma membrane • acetylcholine-gated channel complex • integral component of membrane • cell junction • neuron projection • synapse • postsynaptic membrane Biological process • ion transport • cation transport • signal transduction • synaptic transmission • synaptic transmission, cholinergic • neuromuscular synaptic transmission • response to nicotine • regulation of membrane potential • neurological system process • protein heterooligomerization • cation transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1135	110902
Ensembl	ENSG00000120903	ENSMUSG00000022041
UniProt	Q15822	Q91X60
RefSeq (mRNA)	NM_000742	NM_144803
RefSeq (protein)	NP_000733	NP_659052
Location (UCSC)	Chr 8: 27.46 – 27.48 Mb	Chr 14: 66.14 – 66.15 Mb
PubMed search

Neuronal acetylcholine receptor subunit alpha-2 also known as nAChRα2 is a protein that in humans is encoded by the CHRNA2 gene.^[1][2]

Function

Knockout of this gene in mice potentiates nicotine-modulated behaviors.^[3]

See also

• Nicotinic acetylcholine receptor

References

1. Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
2. "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)".
3. Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J (May 2013). "Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors". J. Neurosci. 33 (18): 7728–41. doi:10.1523/JNEUROSCI.4731-12.2013. PMID 23637165.

Further reading

• Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology 147: 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266.
• Wood S, Schertzer M, Yaremko ML (1995). "Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA". Somat. Cell Mol. Genet. 21 (2): 147–50. doi:10.1007/BF02255790. PMID 7570187.
• García-Colunga J, Miledi R (1995). "Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 92 (7): 2919–23. doi:10.1073/pnas.92.7.2919. PMC 42330. PMID 7708749.
• Elliott KJ, Ellis SB, Berckhan KJ; et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617.
• Chavez-Noriega LE, Crona JH, Washburn MS; et al. (1997). "Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes". J. Pharmacol. Exp. Ther. 280 (1): 346–56. PMID 8996215.
• Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand) 43 (3): 433–42. PMID 9193799.
• Sato KZ, Fujii T, Watanabe Y; et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173.
• Bertrand D, Picard F, Le Hellard S; et al. (2002). "How mutations in the nAChRs can cause ADNFLE epilepsy". Epilepsia. 43 Suppl 5: 112–22. doi:10.1046/j.1528-1157.43.s.5.16.x. PMID 12121305.
• Jin P, Fu GK, Wilson AD; et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Nusbaum C, Mikkelsen TS, Zody MC; et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.
• Aridon P, Marini C, Di Resta C; et al. (2006). "Increased Sensitivity of the Neuronal Nicotinic Receptor α2 Subunit Causes Familial Epilepsy with Nocturnal Wandering and Ictal Fear". Am. J. Hum. Genet. 79 (2): 342–50. doi:10.1086/506459. PMC 1559502. PMID 16826524.

External links

• CHRNA2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.