Zinc-activated ion channel

Zinc activated ligand-gated ion channel
Identifiers
Symbols	ZACN ; L2; LGICZ; LGICZ1; ZAC; ZAC1
External IDs	OMIM: 610935 HomoloGene: 52296 IUPHAR: 587 ChEMBL: 1628479 GeneCards: ZACN Gene
Gene ontology Molecular function • acetylcholine-activated cation-selective channel activity • zinc ion binding • ligand-gated ion channel activity • acetylcholine receptor activity • acetylcholine binding Cellular component • plasma membrane • acetylcholine-gated channel complex • neuron projection • synapse Biological process • signal transduction • synaptic transmission, cholinergic • neuromuscular synaptic transmission • response to zinc ion • ion transmembrane transport • response to nicotine • regulation of membrane potential • neurological system process • cation transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	353174	n/a
Ensembl	ENSG00000186919	n/a
UniProt	Q401N2	n/a
RefSeq (mRNA)	NM_180990	n/a
RefSeq (protein)	NP_851321	n/a
Location (UCSC)	Chr 17: 76.07 – 76.08 Mb	n/a
PubMed search		n/a

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.^[1]

ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach.^[1][2] The endogenous ligand for ZAC is thought to be Zn²⁺, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.^[1]

References

1. Davies PA, Wang W, Hales TG, Kirkness EF (2003). "A novel class of ligand-gated ion channel is activated by Zn2+". J. Biol. Chem. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728.
2. Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochem Biophys Res Commun 335 (2): 227–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.