GRIN1

Glutamate receptor, ionotropic, N-methyl D-aspartate 1
Rendering of GRIN1 from PDB 2NR1​
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2HQW​, 2NR1​, 3BYA​
Identifiers
Symbols	GRIN1 ; GluN1; MRD8; NMD-R1; NMDA1; NMDAR1; NR1
External IDs	OMIM: 138249 MGI: 95819 HomoloGene: 7187 IUPHAR: 455 ChEMBL: 2015 GeneCards: GRIN1 Gene
Gene ontology Molecular function • NMDA glutamate receptor activity • extracellular-glutamate-gated ion channel activity • calcium channel activity • calcium ion binding • protein binding • calmodulin binding • glycine binding • glutamate binding • enzyme binding • voltage-gated cation channel activity • glutamate receptor binding • neurotransmitter binding • protein heterodimerization activity Cellular component • endoplasmic reticulum • plasma membrane • integral component of plasma membrane • synaptic vesicle • cell surface • postsynaptic density • NMDA selective glutamate receptor complex • cell junction • dendrite • dendrite membrane • neuron projection • neuronal cell body • synaptic cleft • terminal bouton • dendritic spine • dendritic branch • synapse • postsynaptic membrane • excitatory synapse • neuronal postsynaptic density Biological process • conditioned taste aversion • suckling behavior • response to amphetamine • cation transport • cellular calcium ion homeostasis • synaptic transmission • axon guidance • respiratory gaseous exchange • long-term memory • adult locomotory behavior • olfactory learning • visual learning • propylene metabolic process • sensory perception of pain • pons maturation • cerebral cortex development • ion transmembrane transport • regulation of ion transmembrane transport • social behavior • ionotropic glutamate receptor signaling pathway • synaptic transmission, glutamatergic • regulation of membrane potential • positive regulation of apoptotic process • response to morphine • negative regulation of neuron apoptotic process • regulation of respiratory gaseous exchange • response to ethanol • positive regulation of transcription from RNA polymerase II promoter • ephrin receptor signaling pathway • regulation of long-term neuronal synaptic plasticity • rhythmic process • regulation of dendrite morphogenesis • regulation of axonogenesis • protein tetramerization • response to calcium ion • regulation of synapse assembly • calcium ion homeostasis • excitatory postsynaptic potential • prepulse inhibition • male mating behavior • response to fungicide • calcium ion transmembrane transport • cellular response to manganese ion • positive regulation of excitatory postsynaptic potential Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2902	14810
Ensembl	ENSG00000176884	ENSMUSG00000026959
UniProt	Q05586	P35438
RefSeq (mRNA)	NM_000832	NM_001177656
RefSeq (protein)	NP_000823	NP_001171127
Location (UCSC)	Chr 9: 137.14 – 137.17 Mb	Chr 2: 25.29 – 25.32 Mb
PubMed search

Glutamate [NMDA] receptor subunit zeta-1 is a protein that in humans is encoded by the GRIN1 gene.^[1][2]

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. Although the sequence of exon 5 is identical in human and rat, the alternative exon 5 splicing in rat has yet to be demonstrated in human. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits.^[2]

See also

• NMDA receptor

References

1. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (Jun 1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science 256 (5060): 1217–21. doi:10.1126/science.256.5060.1217. PMID 1350383.
2. "Entrez Gene: GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1".

Further reading

• Lin JW, Wyszynski M, Madhavan R, et al. (1998). "Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1.". J. Neurosci. 18 (6): 2017–27. PMID 9482789.
• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology 19 (4–5): 683–8. PMID 9745929.
• Adriani W, Felici A, Sargolini F, et al. (1999). "N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes". Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 123 (1–2): 52–9. doi:10.1007/s002210050544. PMID 9835392.
• Dingledine R, Borges K, Bowie D, Traynelis SF (1999). "The glutamate receptor ion channels". Pharmacol. Rev. 51 (1): 7–61. PMID 10049997.
• King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity". Microbes Infect. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.
• Zimmer M, Fink TM, Franke Y, et al. (1995). "Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1)". Gene 159 (2): 219–23. doi:10.1016/0378-1119(95)00044-7. PMID 7622053.
• Karp SJ, Masu M, Eki T, et al. (1993). "Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor". J. Biol. Chem. 268 (5): 3728–33. PMID 7679115.
• Younkin DP, Tang CM, Hardy M, et al. (1993). "Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2174–8. doi:10.1073/pnas.90.6.2174. PMC 46048. PMID 7681588.
• Planells-Cases R, Sun W, Ferrer-Montiel AV, Montal M (1993). "Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain". Proc. Natl. Acad. Sci. U.S.A. 90 (11): 5057–61. doi:10.1073/pnas.90.11.5057. PMC 46653. PMID 7685113.
• Magnuson DS, Knudsen BE, Geiger JD, et al. (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237.
• Foldes RL, Rampersad V, Kamboj RK (1994). "Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits". Gene 147 (2): 303–4. doi:10.1016/0378-1119(94)90089-2. PMID 7926821.
• Sheng M, Cummings J, Roldan LA, et al. (1994). "Changing subunit composition of heteromeric NMDA receptors during development of rat cortex". Nature 368 (6467): 144–7. doi:10.1038/368144a0. PMID 8139656.
• Tingley WG, Roche KW, Thompson AK, Huganir RL (1993). "Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain". Nature 364 (6432): 70–3. doi:10.1038/364070a0. PMID 8316301.
• Foldes RL, Rampersad V, Kamboj RK (1993). "Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing". Gene 131 (2): 293–8. doi:10.1016/0378-1119(93)90309-Q. PMID 8406025.
• Collins C, Duff C, Duncan AM, et al. (1993). "Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively". Genomics 17 (1): 237–9. doi:10.1006/geno.1993.1311. PMID 8406459.
• Lannuzel A, Lledo PM, Lamghitnia HO, et al. (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci. 7 (11): 2285–93. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID 8563977.
• Corasaniti MT, Melino G, Navarra M, et al. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID 8581564.
• Ehlers MD, Zhang S, Bernhadt JP, Huganir RL (1996). "Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit". Cell 84 (5): 745–55. doi:10.1016/S0092-8674(00)81052-1. PMID 8625412.
• Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS 10 (5): 463–8. doi:10.1097/00002030-199605000-00003. PMID 8724036.