GABRD

Gamma-aminobutyric acid (GABA) A receptor, delta
Identifiers
Symbols	GABRD ; EIG10; EJM7; GEFSP5
External IDs	OMIM: 137163 MGI: 95622 HomoloGene: 55489 IUPHAR: 416 ChEMBL: 3591 GeneCards: GABRD Gene
Gene ontology Molecular function • GABA-A receptor activity • extracellular ligand-gated ion channel activity • chloride channel activity • protein binding Cellular component • integral component of plasma membrane • cell junction • chloride channel complex • neuron projection • synapse • postsynaptic membrane • GABA-A receptor complex Biological process • transport • signal transduction • synaptic transmission • regulation of membrane potential • neurological system process • chloride transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2563	14403
Ensembl	ENSG00000187730	ENSMUSG00000029054
UniProt	O14764	P22933
RefSeq (mRNA)	NM_000815	NM_008072
RefSeq (protein)	NP_000806	NP_032098
Location (UCSC)	Chr 1: 2.02 – 2.03 Mb	Chr 4: 155.38 – 155.4 Mb
PubMed search

Gamma-aminobutyric acid receptor subunit delta is a protein that in humans is encoded by the GABRD gene.^[1][2][3]

Function

γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA_A receptors, which are ligand-gated chloride channels. The GABA_A receptor is generally pentameric. Its five subunits are alpha, beta, gamma, delta, and rho. The GABRD gene encodes the delta subunit.^[3]

Cell type-specific expression

In a technical comparison between quantitative reverse transcriptase PCR and digital PCR, the expression of the rat gabrd gene was examined across three cell types in the somatosensory cortex: neurogliaform cells, fast spiking basket cells and pyramidal cells.^[4] Gene expression was detected in all three cell types, but showed marked enrichment in neurogliaform cells versus the other cell types examined.^[4]

See also

• GABA_A receptor

References

1. Sommer B, Poustka A, Spurr NK, Seeburg PH (Oct 1990). "The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1". DNA and Cell Biology 9 (8): 561–8. doi:10.1089/dna.1990.9.561. PMID 2176788.
2. Emberger W, Windpassinger C, Petek E, Kroisel PM, Wagner K (Sep 2000). "Assignment of the human GABAA receptor delta-subunit gene (GABRD) to chromosome band 1p36.3 distal to marker NIB1364 by radiation hybrid mapping". Cytogenetics and Cell Genetics 89 (3-4): 281–2. doi:10.1159/000015636. PMID 10965146.
3. "Entrez Gene: GABRD gamma-aminobutyric acid (GABA) A receptor, delta".
4. Faragó N, Kocsis ÁK, Lovas S, Molnár G, Boldog E, Rózsa M, Szemenyei V, Vámos E, Nagy LI, Tamás G, Puskás LG (Jun 2013). "Digital PCR to determine the number of transcripts from single neurons after patch-clamp recording". BioTechniques 54 (6): 327–36. doi:10.2144/000114029. PMID 23750542.

Further reading

• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Lenzen KP, Heils A, Lorenz S, Hempelmann A, Sander T (Jun 2005). "Association analysis of the Arg220His variation of the human gene encoding the GABA delta subunit with idiopathic generalized epilepsy". Epilepsy Research 65 (1-2): 53–7. doi:10.1016/j.eplepsyres.2005.04.005. PMID 16023832.
• Windpassinger C, Kroisel PM, Wagner K, Petek E (Jun 2002). "The human gamma-aminobutyric acid A receptor delta (GABRD) gene: molecular characterisation and tissue-specific expression". Gene 292 (1-2): 25–31. doi:10.1016/S0378-1119(02)00649-2. PMID 12119096.

External links

• GABRD protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.