GABRP

Gamma-aminobutyric acid (GABA) A receptor, pi
Identifiers
Symbols	GABRP ; MGC126386; MGC126387
External IDs	OMIM: 602729 MGI: 2387597 HomoloGene: 22798 IUPHAR: 419 ChEMBL: 3506 GeneCards: GABRP Gene
Gene ontology Molecular function • GABA-A receptor activity • extracellular ligand-gated ion channel activity • chloride channel activity Cellular component • integral component of plasma membrane • cell junction • chloride channel complex • neuron projection • synapse • postsynaptic membrane • GABA-A receptor complex Biological process • signal transduction • synaptic transmission • regulation of membrane potential • neurological system process • chloride transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2568	216643
Ensembl	ENSG00000094755	ENSMUSG00000020159
UniProt	O00591	Q8QZW7
RefSeq (mRNA)	NM_001291985	NM_146017
RefSeq (protein)	NP_001278914	NP_666129
Location (UCSC)	Chr 5: 170.76 – 170.81 Mb	Chr 11: 33.55 – 33.58 Mb
PubMed search

Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene.^[1][2]

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.^[2]

See also

• GABAA receptor

References

1. Hedblom E, Kirkness EF (Jul 1997). "A novel class of GABAA receptor subunit in tissues of the reproductive system". J Biol Chem 272 (24): 15346–50. doi:10.1074/jbc.272.24.15346. PMID 9182563.
2. "Entrez Gene: GABRP gamma-aminobutyric acid (GABA) A receptor, pi".

Further reading

• Mehta AK, Ticku MK (1999). "An update on GABAA receptors.". Brain Res. Brain Res. Rev. 29 (2–3): 196–217. doi:10.1016/S0165-0173(98)00052-6. PMID 10209232.
• Zafrakas M, Chorovicer M, Klaman I; et al. (2007). "Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue". Int. J. Cancer 118 (6): 1453–9. doi:10.1002/ijc.21517. PMID 16187283.
• Petryshen TL, Middleton FA, Tahl AR; et al. (2006). "Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia". Mol. Psychiatry 10 (12): 1074–88, 1057. doi:10.1038/sj.mp.4001739. PMID 16172613.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Galey D, Becker K, Haughey N; et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Neelands TR, Macdonald RL (1999). "Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors". Mol. Pharmacol. 56 (3): 598–610. PMID 10462548.
• Taylor PM, Thomas P, Gorrie GH; et al. (1999). "Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression". J. Neurosci. 19 (15): 6360–71. PMID 10414965.

External links

• GABRP protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.