GABRR3

Gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene)
Identifiers
Symbols	GABRR3 ; DKFZp781O1955
External IDs	MGI: 3588203 HomoloGene: 26716 IUPHAR: 422 ChEMBL: 2394 GeneCards: GABRR3 Gene
Gene ontology Molecular function • GABA-A receptor activity • extracellular ligand-gated ion channel activity • chloride channel activity • protein domain specific binding Cellular component • cellular_component • plasma membrane • cell junction • chloride channel complex • postsynaptic membrane Biological process • gamma-aminobutyric acid signaling pathway • synaptic transmission • ion transmembrane transport • transmembrane transport • chloride transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	200959	328699
Ensembl	ENSG00000183185	ENSMUSG00000074991
UniProt	A8MPY1	B2RXA8
RefSeq (mRNA)	NM_001105580	NM_001081190
RefSeq (protein)	NP_001099050	NP_001074659
Location (UCSC)	Chr 3: 97.99 – 98.04 Mb	Chr 16: 59.41 – 59.46 Mb
PubMed search

Gamma-aminobutyric acid receptor subunit rho-3 is a protein that in humans is encoded by the GABRR3 gene.^[1] The protein encoded by this gene is a subunit of the GABA_A-ρ receptor.

References

1. Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (October 1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta 1447 (2–3): 307–12. doi:10.1016/S0167-4781(99)00167-0. PMID 10542332.

Further reading

• Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–35. doi:10.1074/jbc.M205162200. PMID 12431995.
• Craddock N, Jones L, Jones IR; et al. (2010). "Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype". Mol. Psychiatry 15 (2): 146–53. doi:10.1038/mp.2008.66. PMID 19078961.
• Alakuijala A, Palgi M, Wegelius K; et al. (2005). "GABA receptor rho subunit expression in the developing rat brain". Brain Res. Dev. Brain Res. 154 (1): 15–23. doi:10.1016/j.devbrainres.2004.09.010. PMID 15617751.
• Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta 1447 (2–3): 307–12. doi:10.1016/S0167-4781(99)00167-0. PMID 10542332.
• Gratacòs M, Costas J, de Cid R; et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
• Muzny DM, Scherer SE, Kaul R; et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.

External links

• GABRR3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)