GABRR2

Gamma-aminobutyric acid (GABA) A receptor, rho 2
Identifiers
Symbol	GABRR2
External IDs	OMIM: 137162 MGI: 95626 HomoloGene: 20471 IUPHAR: 421 ChEMBL: 2375 GeneCards: GABRR2 Gene
Gene ontology Molecular function • GABA-A receptor activity • extracellular ligand-gated ion channel activity • chloride channel activity • protein domain specific binding Cellular component • plasma membrane • integral component of plasma membrane • cell junction • chloride channel complex • neuron projection • synapse • postsynaptic membrane • GABA-A receptor complex Biological process • transport • signal transduction • gamma-aminobutyric acid signaling pathway • synaptic transmission • visual perception • ion transmembrane transport • regulation of membrane potential • neurological system process • transmembrane transport • chloride transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2570	14409
Ensembl	ENSG00000111886	ENSMUSG00000023267
UniProt	P28476	P56476
RefSeq (mRNA)	NM_002043	NM_008076
RefSeq (protein)	NP_002034	NP_032102
Location (UCSC)	Chr 6: 89.26 – 89.32 Mb	Chr 4: 33.06 – 33.1 Mb
PubMed search

Gamma-aminobutyric acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene.^[1][2]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR2 is a member of the rho subunit family.^[2]

See also

• GABA_A-ρ receptor

References

1. Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR (May 1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4". Genomics 12 (4): 801–6. doi:10.1016/0888-7543(92)90312-G. PMID 1315307.
2. "Entrez Gene: GABRR2 gamma-aminobutyric acid (GABA) receptor, rho 2".

Further reading

• Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction.". J. Biol. Chem. 272 (21): 13750–7. doi:10.1074/jbc.272.21.13750. PMID 9153229.
• Kusama T, Hatama K, Sakurai M; et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation.". Neurosci. Lett. 255 (1): 17–20. doi:10.1016/S0304-3940(98)00696-X. PMID 9839716.
• Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.". Biochim. Biophys. Acta 1447 (2–3): 307–12. doi:10.1016/S0167-4781(99)00167-0. PMID 10542332.
• Billups D, Hanley JG, Orme M; et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–50. PMID 11102469.
• Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor". Int. J. Dev. Neurosci. 20 (3–5): 237–46. doi:10.1016/S0736-5748(02)00037-0. PMID 12175859.
• Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–35. doi:10.1074/jbc.M205162200. PMID 12431995.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gamel-Didelon K, Kunz L, Fohr KJ; et al. (2003). "Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells". J. Biol. Chem. 278 (22): 20192–5. doi:10.1074/jbc.M301729200. PMID 12660236.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• GABRR2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.