HTR3C

5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
Identifiers
Symbol	HTR3C
External IDs	OMIM: 610121 HomoloGene: 50847 IUPHAR: 375 ChEMBL: 4795 GeneCards: HTR3C Gene
Gene ontology Molecular function • acetylcholine-activated cation-selective channel activity • serotonin receptor activity • serotonin-activated cation-selective channel activity • acetylcholine receptor activity • acetylcholine binding Cellular component • plasma membrane • acetylcholine-gated channel complex • neuron projection • synapse Biological process • serotonin receptor signaling pathway • synaptic transmission, cholinergic • neuromuscular synaptic transmission • ion transmembrane transport • response to nicotine • regulation of membrane potential • neurological system process • transmembrane transport • cation transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	170572	n/a
Ensembl	ENSG00000178084	n/a
UniProt	Q8WXA8	n/a
RefSeq (mRNA)	NM_130770	n/a
RefSeq (protein)	NP_570126	n/a
Location (UCSC)	Chr 3: 184.05 – 184.06 Mb	n/a
PubMed search		n/a

5-hydroxytryptamine receptor 3C is a protein that in humans is encoded by the HTR3C gene.^[1][2][1] The protein encoded by this gene is a subunit of the 5-HT3 receptor.^[2]

References

1. Niesler B, Frank B, Kapeller J, Rappold GA (Jun 2003). "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E". Gene 310: 101–11. doi:10.1016/S0378-1119(03)00503-1. PMID 12801637.
2. Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ (May 2004). "The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance". Biochem Soc Trans 32 (Pt3): 547–52. doi:10.1042/BST0320547. PMID 15157181.

Further reading

• Karnovsky AM, Gotow LF, McKinley DD, et al. (2003). "A cluster of novel serotonin receptor 3-like genes on human chromosome 3.". Gene 319: 137–48. doi:10.1016/S0378-1119(03)00803-5. PMID 14597179.
• Fasching PA, Kollmannsberger B, Strissel PL, et al. (2008). "Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.". J. Cancer Res. Clin. Oncol. 134 (10): 1079–86. doi:10.1007/s00432-008-0387-1. PMID 18389280.
• Ward MB, Kotasek D, McKinnon RA (2008). "Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy.". Pharmacogenomics 9 (8): 1027–33. doi:10.2217/14622416.9.8.1027. PMID 18681779.

External links

• HTR3C protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)