GABRB2

Gamma-aminobutyric acid (GABA) A receptor, beta 2
Identifiers
Symbols	GABRB2 ; MGC119386; MGC119388; MGC119389
External IDs	OMIM: 600232 MGI: 95620 HomoloGene: 7327 IUPHAR: 411 ChEMBL: 1920 GeneCards: GABRB2 Gene
Gene ontology Molecular function • GABA-A receptor activity • extracellular ligand-gated ion channel activity • inhibitory extracellular ligand-gated ion channel activity • chloride channel activity Cellular component • cytosol • plasma membrane • integral component of plasma membrane • cell junction • chloride channel complex • neuron projection • synapse • postsynaptic membrane • extracellular exosome • GABA-A receptor complex Biological process • transport • gamma-aminobutyric acid signaling pathway • synaptic transmission • sensory perception of sound • ion transmembrane transport • regulation of membrane potential • negative regulation of neuron apoptotic process • neurological system process • synaptic transmission, GABAergic • transmembrane transport • inner ear receptor cell development • innervation • cellular response to histamine • cochlea development • chloride transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2561	14401
Ensembl	ENSG00000145864	ENSMUSG00000007653
UniProt	P47870	P63137
RefSeq (mRNA)	NM_000813	NM_008070
RefSeq (protein)	NP_000804	NP_032096
Location (UCSC)	Chr 5: 161.29 – 161.55 Mb	Chr 11: 42.42 – 42.63 Mb
PubMed search

Gamma-aminobutyric acid receptor subunit beta-2 is a protein that in humans is encoded by the GABRB2 gene.^[1][2]

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.^[2]

Interactions

GABRB2 has been shown to interact with TRAK2.^[3]

See also

• GABAA receptor

References

1. Russek SJ, Farb DH (Mar 1995). "Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform". Genomics 23 (3): 528–33. doi:10.1006/geno.1994.1539. PMID 7851879.
2. "Entrez Gene: GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2".
3. Beck, Mike; Brickley Kieran; Wilkinson Helen L; Sharma Seema; Smith Miriam; Chazot Paul L; Pollard Simon; Stephenson F Anne (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". J. Biol. Chem. (United States) 277 (33): 30079–90. doi:10.1074/jbc.M200438200. ISSN 0021-9258. PMID 12034717.

Further reading

• Moss SJ, Doherty CA, Huganir RL (1992). "Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor". J. Biol. Chem. 267 (20): 14470–6. PMID 1321150.
• Kellenberger S, Malherbe P, Sigel E (1993). "Function of the alpha 1 beta 2 gamma 2S gamma-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites". J. Biol. Chem. 267 (36): 25660–3. PMID 1334482.
• McKinley DD, Lennon DJ, Carter DB (1995). "Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor". Brain Res. Mol. Brain Res. 28 (1): 175–9. doi:10.1016/0169-328X(94)00228-7. PMID 7707873.
• Tögel M, Mossier B, Fuchs K, Sieghart W (1994). "gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties". J. Biol. Chem. 269 (17): 12993–8. PMID 8175718.
• Hadingham KL, Wingrove PB, Wafford KA, et al. (1994). "Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors". Mol. Pharmacol. 44 (6): 1211–8. PMID 8264558.
• Akbarian S, Huntsman MM, Kim JJ, et al. (1996). "GABAA receptor subunit gene expression in human prefrontal cortex: comparison of schizophrenics and controls". Cereb. Cortex 5 (6): 550–60. doi:10.1093/cercor/5.6.550. PMID 8590827.
• Longson D, Longson CM, Jones EG (1997). "Localization of CAM II kinase-alpha, GAD, GluR2 and GABA(A) receptor subunit mRNAs in the human entorhinal cortex". Eur. J. Neurosci. 9 (4): 662–75. doi:10.1111/j.1460-9568.1997.tb01415.x. PMID 9153573.
• Russek SJ (1999). "Evolution of GABA(A) receptor diversity in the human genome". Gene 227 (2): 213–22. doi:10.1016/S0378-1119(98)00594-0. PMID 10023064.
• Bonnert TP, McKernan RM, Farrar S, et al. (1999). "theta, a novel gamma-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–6. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790.
• Brooks-Kayal AR, Shumate MD, Jin H, et al. (1999). "Human neuronal gamma-aminobutyric acid(A) receptors: coordinated subunit mRNA expression and functional correlates in individual dentate granule cells". J. Neurosci. 19 (19): 8312–8. PMID 10493732.
• Buckley ST, Eckert AL, Dodd PR (2006). "Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex". Ann. N. Y. Acad. Sci. 914: 58–64. doi:10.1111/j.1749-6632.2000.tb05183.x. PMID 11085308.
• Salim K, Fenton T, Bacha J, et al. (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". J. Biol. Chem. 277 (18): 15482–5. doi:10.1074/jbc.M201539200. PMID 11854302.
• Beck M, Brickley K, Wilkinson HL, et al. (2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". J. Biol. Chem. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717.
• Iyer SP, Akimoto Y, Hart GW (2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". J. Biol. Chem. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang J, Liu S, Haditsch U, et al. (2003). "Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses". J. Neurosci. 23 (3): 826–36. PMID 12574411.
• Pirker S, Schwarzer C, Czech T, et al. (2003). "Increased expression of GABA(A) receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy". J. Neuropathol. Exp. Neurol. 62 (8): 820–34. PMID 14503638.
• Mercik K, Pytel M, Mozrzymas JW (2004). "Recombinant alpha 1 beta 2 gamma 2 GABA(A) receptors expressed in HEK293 and in QT6 cells show different kinetics". Neurosci. Lett. 352 (3): 195–8. doi:10.1016/j.neulet.2003.08.060. PMID 14625018.
• Lo WS, Lau CF, Xuan Z, et al. (2005). "Association of SNPs and haplotypes in GABAA receptor beta2 gene with schizophrenia". Mol. Psychiatry 9 (6): 603–8. doi:10.1038/sj.mp.4001461. PMID 14699426.

External links

• GABRB2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.