GRIK3

Glutamate receptor, ionotropic, kainate 3
Identifiers
Symbols	GRIK3 ; EAA5; GLR7; GLUR7; GluK3; GluR7a
External IDs	OMIM: 138243 MGI: 95816 HomoloGene: 73901 IUPHAR: 452 ChEMBL: 3684 GeneCards: GRIK3 Gene
Gene ontology Molecular function • adenylate cyclase inhibiting G-protein coupled glutamate receptor activity • ionotropic glutamate receptor activity • extracellular-glutamate-gated ion channel activity • glutamate receptor activity • kainate selective glutamate receptor activity Cellular component • plasma membrane • integral component of plasma membrane • cell junction • axon • dendrite • dendrite cytoplasm • kainate selective glutamate receptor complex • presynaptic membrane • terminal bouton • perikaryon • postsynaptic membrane Biological process • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway • glutamate receptor signaling pathway • G-protein coupled glutamate receptor signaling pathway • synaptic transmission • ion transmembrane transport • ionotropic glutamate receptor signaling pathway • synaptic transmission, glutamatergic • regulation of membrane potential • negative regulation of synaptic transmission, glutamatergic Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2899	14807
Ensembl	ENSG00000163873	ENSMUSG00000001985
UniProt	Q13003	B1AS29
RefSeq (mRNA)	NM_000831	NM_001081097
RefSeq (protein)	NP_000822	NP_001074566
Location (UCSC)	Chr 1: 36.8 – 37.03 Mb	Chr 4: 125.49 – 125.71 Mb
PubMed search

Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene.^[1][2]

This gene encodes a protein that belongs to the ligand-gated ionic channel family. It can coassemble with either GRIK4 or GRIK5 to form heteromeric receptors and acts as an excitatory neurotransmitter at many synapses in the central nervous system. RNA editing in the mRNA has been reported.^[2]

See also

• Kainate receptor

References

1. Puranam RS, Eubanks JH, Heinemann SF, McNamara JO (Apr 1994). "Chromosomal localization of gene for human glutamate receptor subunit-7". Somat Cell Mol Genet 19 (6): 581–8. doi:10.1007/BF01233385. PMID 8128318.
2. "Entrez Gene: GRIK3 glutamate receptor, ionotropic, kainate 3".

Further reading

• Nutt SL, Hoo KH, Rampersad V, et al. (1995). "Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites.". Recept. Channels 2 (4): 315–26. PMID 7719709.
• Roche KW, Raymond LA, Blackstone C, Huganir RL (1994). "Transmembrane topology of the glutamate receptor subunit GluR6.". J. Biol. Chem. 269 (16): 11679–82. PMID 8163463.
• Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.". Neuroscience 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Schiffer HH, Swanson GT, Masliah E, Heinemann SF (2001). "Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains.". J. Neurosci. 20 (24): 9025–33. PMID 11124978.
• Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.". FEBS Lett. 514 (2-3): 184–8. doi:10.1016/S0014-5793(02)02361-X. PMID 11943148.
• Begni S, Popoli M, Moraschi S, et al. (2002). "Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia.". Mol. Psychiatry 7 (4): 416–8. doi:10.1038/sj.mp.4000987. PMID 11986986.
• Delorme R, Krebs MO, Chabane N, et al. (2004). "Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.". NeuroReport 15 (4): 699–702. doi:10.1097/00001756-200403220-00025. PMID 15094479.
• Preuss UW, Zill P, Koller G, et al. (2006). "Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics.". Pharmacogenomics J. 6 (1): 34–41. doi:10.1038/sj.tpj.6500343. PMID 16314883.
• Samochowiec J, Grzywacz A, Kucharska-Mazur J, et al. (2006). "Family-based and case-control association studies of glutamate receptor GRIK3 Ser310Ala polymorphism in Polish patients and families with alcohol dependence.". Neurosci. Lett. 396 (2): 159–62. doi:10.1016/j.neulet.2005.11.030. PMID 16356644.
• Schiffer HH, Heinemann SF (2007). "Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (1): 20–6. doi:10.1002/ajmg.b.30374. PMID 16958029.
• Kim JM, Lee KH, Jeon YJ, et al. (2007). "Identification of genes related to Parkinson's disease using expressed sequence tags.". DNA Res. 13 (6): 275–86. doi:10.1093/dnares/dsl016. PMID 17213182.

External links

• GRIK3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.