HTR3B

5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
Identifiers
Symbols	HTR3B ; 5-HT3B
External IDs	OMIM: 604654 MGI: 1861899 HomoloGene: 38131 IUPHAR: 374 ChEMBL: 3895 GeneCards: HTR3B Gene
Gene ontology Molecular function • acetylcholine-activated cation-selective channel activity • serotonin receptor activity • ion channel activity • serotonin-activated cation-selective channel activity • acetylcholine receptor activity • acetylcholine binding Cellular component • plasma membrane • integral component of plasma membrane • acetylcholine-gated channel complex • cell surface • neuron projection • synapse • postsynaptic membrane Biological process • transport • serotonin receptor signaling pathway • synaptic transmission • synaptic transmission, cholinergic • neuromuscular synaptic transmission • ion transmembrane transport • response to nicotine • regulation of membrane potential • neurological system process • transmembrane transport • cation transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9177	57014
Ensembl	ENSG00000149305	ENSMUSG00000008590
UniProt	O95264	Q9JHJ5
RefSeq (mRNA)	NM_006028	NM_020274
RefSeq (protein)	NP_006019	NP_064670
Location (UCSC)	Chr 11: 113.9 – 113.95 Mb	Chr 9: 48.94 – 48.96 Mb
PubMed search

5-hydroxytryptamine (serotonin) receptor 3B, also known as HTR3B, is a human gene. The protein encoded by this gene is a subunit of the 5-HT3 receptor.^[1][2]

References

1. Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF (January 1999). "The 5-HT3B subunit is a major determinant of serotonin-receptor function". Nature 397 (6717): 359–63. doi:10.1038/16941. PMID 9950429.
2. Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG (October 1999). "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit". J. Biol. Chem. 274 (43): 30799–810. doi:10.1074/jbc.274.43.30799. PMID 10521471.

Further reading

• Need AC, Keefe RS, Ge D, et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis". Eur. J. Hum. Genet. 17 (7): 946–57. doi:10.1038/ejhg.2008.264. PMC 2986499. PMID 19156168.
• Meineke C, Tzvetkov MV, Bokelmann K, et al. (2008). "Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene". Pharmacogenet. Genomics 18 (3): 219–30. doi:10.1097/FPC.0b013e3282f51092. PMID 18300944.
• Levran O, Londono D, O'Hara K, et al. (2008). "Genetic susceptibility to heroin addiction; a candidate-gene association study". Genes, Brain and Behavior 7 (7): 720–9. doi:10.1111/j.1601-183X.2008.00410.x. PMC 2885890. PMID 18518925.
• Kato M, Fukuda T, Wakeno M, et al. (2006). "Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients". Neuropsychobiology 53 (4): 186–95. doi:10.1159/000094727. PMID 16874005.
• Hu XQ, Peoples RW (2008). "The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor". J. Biol. Chem. 283 (11): 6826–31. doi:10.1074/jbc.M707571200. PMID 18187416.
• Krzywkowski K, Davies PA, Feinberg-Zadek PL, et al. (2008). "High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor". Proc. Natl. Acad. Sci. U.S.A. 105 (2): 722–7. doi:10.1073/pnas.0708454105. PMC 2206603. PMID 18184810.
• Ji X, Takahashi N, Branko A, et al. (2008). "An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population". Nagoya journal of medical science 70 (1–2): 11–7. PMID 18807291.
• Kato M, Serretti A (2008). "Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder". Mol. Psychiatry 15 (5): 473–500. doi:10.1038/mp.2008.116. PMID 18982004.
• Walstab J, Hammer C, Bönisch H, et al. (2008). "Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors". Pharmacogenet. Genomics 18 (9): 793–802. doi:10.1097/FPC.0b013e3283050117. PMID 18698232.
• Yosifova A, Mushiroda T, Stoianov D, et al. (2009). "Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population". Journal of Affective Disorders 117 (1–2): 87–97. doi:10.1016/j.jad.2008.12.021. PMID 19328558.
• Tzvetkov MV, Meineke C, Oetjen E, et al. (2007). "Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine". Gene 386 (1–2): 52–62. doi:10.1016/j.gene.2006.08.002. PMID 17010535.
• Oades RD, Lasky-Su J, Christiansen H, et al. (2008). "The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis". Behavioral and Brain Functions 4: 48. doi:10.1186/1744-9081-4-48. PMC 2577091. PMID 18937842.
• Fasching PA, Kollmannsberger B, Strissel PL, et al. (2008). "Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy". J. Cancer Res. Clin. Oncol. 134 (10): 1079–86. doi:10.1007/s00432-008-0387-1. PMID 18389280.
• Tanaka M, Kobayashi D, Murakami Y, et al. (2008). "Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea". Int. J. Neuropsychopharmacol. 11 (2): 261–7. doi:10.1017/S1461145707007985. PMID 17697394.
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
• Krzywkowski K, Davies PA, Irving AJ, et al. (2008). "Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling". Pharmacogenet. Genomics 18 (12): 1027–40. doi:10.1097/FPC.0b013e328310f950. PMID 19008750.
• Smith AK, Dimulescu I, Falkenberg VR, et al. (2008). "Genetic evaluation of the serotonergic system in chronic fatigue syndrome". Psychoneuroendocrinology 33 (2): 188–97. doi:10.1016/j.psyneuen.2007.11.001. PMID 18079067.
• de Krom M, Staal WG, Ophoff RA, et al. (2009). "A common variant in DRD3 receptor is associated with autism spectrum disorder". Biol. Psychiatry 65 (7): 625–30. doi:10.1016/j.biopsych.2008.09.035. PMID 19058789.
• Ducci F, Enoch MA, Yuan Q, et al. (2009). "HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power—an intermediate phenotype for alcoholism and co-morbid behaviors". Alcohol 43 (1): 73–84. doi:10.1016/j.alcohol.2008.09.005. PMC 2754808. PMID 19185213.

External links

• HTR3B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)