CLCA4
| Chloride channel accessory 4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | CLCA4 ; CaCC; CaCC2 | ||||||||||||
| External IDs | MGI: 2139790 HomoloGene: 40808 GeneCards: CLCA4 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 22802 | 99663 | |||||||||||
| Ensembl | ENSG00000016602 | ENSMUSG00000068547 | |||||||||||
| UniProt | Q14CN2 | E9QLH0 | |||||||||||
| RefSeq (mRNA) | NM_012128 | NM_207208 | |||||||||||
| RefSeq (protein) | NP_036260 | NP_997091 | |||||||||||
| Location (UCSC) |
Chr 1: 86.55 – 86.58 Mb |
Chr 3: 144.95 – 144.98 Mb | |||||||||||
| PubMed search | |||||||||||||
Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4 gene. The protein encoded by this gene is a chloride channel.[1] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[2]
See also
References
- ↑ Agnel M, Vermat T, Culouscou JM (July 1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792.
- ↑ Pawłowski K, Lepistö M, Meinander N; et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels.". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849.
Further reading
- Liu QH, Williams DA, McManus C; et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. doi:10.1073/pnas.090521697. PMC 18318. PMID 10758170.
- Ritzka M, Stanke F, Jansen S; et al. (2004). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.". Hum. Genet. 115 (6): 483–91. doi:10.1007/s00439-004-1190-y. PMID 15490240.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Pauli BU, Abdel-Ghany M, Cheng HC; et al. (2000). "Molecular characteristics and functional diversity of CLCA family members.". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307.
External links
- CLCA3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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