TPCN2

Two pore segment channel 2
Identifiers
Symbols	TPCN2 ; SHEP10; TPC2
External IDs	OMIM: 612163 MGI: 2385297 HomoloGene: 16375 IUPHAR: 393 GeneCards: TPCN2 Gene
Gene ontology Molecular function • voltage-gated calcium channel activity • protein binding • protein kinase binding • identical protein binding • NAADP-sensitive calcium-release channel activity Cellular component • lysosomal membrane • plasma membrane • endosome membrane • integral component of membrane Biological process • calcium ion transport • cellular calcium ion homeostasis • smooth muscle contraction • lysosome organization • calcium-mediated signaling • response to vitamin D • ion transmembrane transport • regulation of ion transmembrane transport • release of sequestered calcium ion into cytosol • transmembrane transport • calcium ion transmembrane transport • membrane depolarization during action potential Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	219931	233979
Ensembl	ENSG00000162341	ENSMUSG00000048677
UniProt	Q8NHX9	Q8BWC0
RefSeq (mRNA)	NM_139075	NM_146206
RefSeq (protein)	NP_620714	NP_666318
Location (UCSC)	Chr 11: 69.05 – 69.09 Mb	Chr 7: 145.25 – 145.28 Mb
PubMed search

Two pore segment channel 2 (TPC2) is a human protein encoded by the TPCN2 is a protein which in humans is encoded by the TPCN2 gene.^[1] TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).^[2]

See also

• Two-pore channel

References

1. "Entrez Gene: two pore segment channel 2".
2. Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.

Further reading

• Sulem P, Gudbjartsson DF, Stacey SN, et al. (2008). "Two newly identified genetic determinants of pigmentation in Europeans.". Nat. Genet. 40 (7): 835–7. doi:10.1038/ng.160. PMID 18488028.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels.". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Calcraft PJ, Ruas M, Pan Z, et al. (2009). "NAADP mobilizes calcium from acidic organelles through two-pore channels.". Nature 459 (7246): 596–600. doi:10.1038/nature08030. PMC 2761823. PMID 19387438.
• Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification.". Nature 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.
• Fu GK, Wang JT, Yang J, et al. (2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.

External links

• TPCN2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)