KCNK17
| Potassium channel, two pore domain subfamily K, member 17 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | KCNK17 ; K2p17.1; TALK-2; TALK2; TASK-4; TASK4 | ||||||||||||
| External IDs | OMIM: 607370 HomoloGene: 88928 IUPHAR: 526 GeneCards: KCNK17 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 89822 | n/a | |||||||||||
| Ensembl | ENSG00000124780 | n/a | |||||||||||
| UniProt | Q96T54 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001135111 | n/a | |||||||||||
| RefSeq (protein) | NP_001128583 | n/a | |||||||||||
| Location (UCSC) |
Chr 6: 39.3 – 39.31 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
Potassium channel subfamily K member 17 is a protein that in humans is encoded by the KCNK17 gene.[1][2]
This gene encodes K2P17.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel, primarily expressed in the pancreas, is activated at alkaline pH.[2]
See also
References
- ↑ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
- 1 2 "Entrez Gene: KCNK17 potassium channel, subfamily K, member 17".
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Girard C, Duprat F, Terrenoire C, et al. (2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem. Biophys. Res. Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID 11263999.
- Decher N, Maier M, Dittrich W, et al. (2001). "Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family". FEBS Lett. 492 (1–2): 84–9. doi:10.1016/S0014-5793(01)02222-0. PMID 11248242.
External links
- KCNK17 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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