KCNA5

Potassium channel, voltage gated shaker related subfamily A, member 5

Identifiers

KCNA5 ; ATFB7; HCK1; HK2; HPCN1; KV1.5; PCN1

External IDs

OMIM: 176267 MGI: 96662 HomoloGene: 1683 IUPHAR: 542 ChEMBL: 4306 GeneCards: KCNA5 Gene

Gene ontology
Molecular function	• receptor binding • delayed rectifier potassium channel activity • protein binding • outward rectifier potassium channel activity • potassium channel inhibitor activity • protein kinase binding • alpha-actinin binding • voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization • voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization • voltage-gated potassium channel activity involved in SA node cell action potential repolarization • scaffold protein binding
Cellular component	• endoplasmic reticulum • Golgi apparatus • cytosol • plasma membrane • integral component of plasma membrane • caveola • voltage-gated potassium channel complex • intercalated disc • Z disc • potassium channel complex • membrane raft • intracellular canaliculus • perinuclear region of cytoplasm
Biological process	• response to hypoxia • potassium ion transport • synaptic transmission • response to mechanical stimulus • response to organic substance • regulation of vasoconstriction • regulation of membrane potential • response to hydrogen peroxide • regulation of potassium ion transport • negative regulation of potassium ion transport • regulation of insulin secretion • protein homooligomerization • negative regulation of cytosolic calcium ion concentration • potassium ion homeostasis • response to hyperoxia • membrane hyperpolarization • regulation of atrial cardiac muscle cell membrane repolarization • potassium ion export • potassium ion transmembrane transport • atrial cardiac muscle cell action potential • membrane repolarization during bundle of His cell action potential • membrane repolarization during SA node cell action potential • regulation of heart rate by cardiac conduction • positive regulation of G1/S transition of mitotic cell cycle • positive regulation of myoblast proliferation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
5.04 – 5.05 Mb

Chr 6:
126.53 – 126.7 Mb

PubMed search

Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or K_v1.5, is a protein that in humans is encoded by the KCNA5 gene.^[1]

Function

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12.^[1] Mutations in this gene have been related to both atrial fibrillation ^[2] and sudden cardiac death.^[3] KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.

Interactions

KCNA5 has been shown to interact with DLG4^[4]^[5] and Actinin, alpha 2.^[4]^[6]

References

1 2 "Entrez Gene: KCNA5 potassium voltage-gated channel, shaker-related subfamily, member 5".
↑ Olson TM, Alekseev AE, Liu XK, Park S, Zingman LV, Bienengraeber M, Sattiraju S, Ballew JD, Jahangir A, Terzic A (Jul 2006). "Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation". Human Molecular Genetics 15 (14): 2185–91. doi:10.1093/hmg/ddl143. PMID 16772329.
↑ Nielsen NH, Winkel BG, Kanters JK, Schmitt N, Hofman-Bang J, Jensen HS, Bentzen BH, Sigurd B, Larsen LA, Andersen PS, Haunsø S, Kjeldsen K, Grunnet M, Christiansen M, Olesen SP (Mar 2007). "Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients". Biochemical and Biophysical Research Communications 354 (3): 776–82. doi:10.1016/j.bbrc.2007.01.048. PMID 17266934.
1 2 Eldstrom J, Choi WS, Steele DF, Fedida D (Jul 2003). "SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism". FEBS Letters 547 (1-3): 205–11. doi:10.1016/S0014-5793(03)00668-9. PMID 12860415.
↑ Eldstrom J, Doerksen KW, Steele DF, Fedida D (Nov 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS Letters 531 (3): 529–37. doi:10.1016/S0014-5793(02)03572-X. PMID 12435606.
↑ Maruoka ND, Steele DF, Au BP, Dan P, Zhang X, Moore ED, Fedida D (May 2000). "alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells". FEBS Letters 473 (2): 188–94. doi:10.1016/S0014-5793(00)01521-0. PMID 10812072.

External links

Kv1.5 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
KCNA5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia - version of the Sunday, November 22, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

KCNA5

Function

Interactions

See also

References

Further reading

External links