SCN4B

Sodium channel, voltage gated, type IV beta subunit
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4MZ2​, 4MZ3​
Identifiers
Symbols	SCN4B ; ATFB17; LQT10; Navbeta4
External IDs	OMIM: 608256 MGI: 2687406 HomoloGene: 18384 ChEMBL: 4689 GeneCards: SCN4B Gene
Gene ontology Molecular function • voltage-gated sodium channel activity • sodium channel regulator activity • ion channel binding • voltage-gated sodium channel activity involved in cardiac muscle cell action potential Cellular component • voltage-gated sodium channel complex • intercalated disc • intrinsic component of plasma membrane Biological process • sodium ion transport • positive regulation of sodium ion transport • sodium ion transmembrane transport • cardiac muscle contraction • regulation of ventricular cardiac muscle cell membrane repolarization • cardiac muscle cell action potential involved in contraction • membrane depolarization during cardiac muscle cell action potential • AV node cell action potential • regulation of heart rate by cardiac conduction • regulation of sodium ion transmembrane transporter activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6330	399548
Ensembl	ENSG00000177098	ENSMUSG00000046480
UniProt	Q8IWT1	Q7M729
RefSeq (mRNA)	NM_001142348	NM_001013390
RefSeq (protein)	NP_001135820	NP_001013408
Location (UCSC)	Chr 11: 118.13 – 118.15 Mb	Chr 9: 45.14 – 45.15 Mb
PubMed search

Sodium channel, also known as SCN4B is a protein which in humans is encoded by the SCN4B gene.^[1]

SCN4B is a sodium channel associated with long QT syndrome.^[2]

See also

• Sodium channel

References

1. "Entrez Gene: sodium channel".
2. Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.

Further reading

• Delgado P, GarcÃa-Zueco JC, Rubio-Félix D, Giralt M (1992). "[Idiopathic thrombocytopenic purpura: present knowledge and future expectations]". Sangre 37 (6): 449–56. PMID 1293796.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Yu FH, Westenbroek RE, Silos-Santiago I, et al. (2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.". J. Neurosci. 23 (20): 7577–85. PMID 12930796.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Webb J, Wu FF, Cannon SC (2009). "Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit.". Pflugers Arch. 457 (6): 1253–63. doi:10.1007/s00424-008-0600-8. PMID 18941776.

External links

• GeneReviews/NIH/NCBI/UW entry on Romano-Ward Syndrome
• SCN4B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)