PRKG1

Protein kinase, cGMP-dependent, type I
Rendering based on PDB 1ZXA​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ZXA​, 3NMD​, 3OCP​, 3OD0​, 3OGJ​, 4KU7​, 4KU8​, 4QX5​, 4QXK​
Identifiers
Symbols	PRKG1 ; AAT8; PKG; PRKG1B; PRKGR1B; cGK; cGK 1; cGK1; cGKI; cGKI-BETA; cGKI-alpha
External IDs	OMIM: 176894 MGI: 108174 HomoloGene: 55964 ChEMBL: 4273 GeneCards: PRKG1 Gene
EC number	2.7.11.12
Gene ontology Molecular function • cGMP-dependent protein kinase activity • calcium channel regulator activity • protein binding • ATP binding • cGMP binding Cellular component • cytoplasm • Golgi apparatus • cytosol • plasma membrane Biological process • neuron migration • protein phosphorylation • signal transduction • blood coagulation • dendrite development • cGMP-mediated signaling • actin cytoskeleton organization • forebrain development • regulation of GTPase activity • relaxation of vascular smooth muscle • negative regulation of platelet aggregation • activation of mitophagy in response to mitochondrial depolarization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5592	19091
Ensembl	ENSG00000185532	ENSMUSG00000052920
UniProt	Q13976	P0C605
RefSeq (mRNA)	NM_001098512	NM_001013833
RefSeq (protein)	NP_001091982	NP_001013855
Location (UCSC)	Chr 10: 50.99 – 52.3 Mb	Chr 19: 30.57 – 31.77 Mb
PubMed search

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.^[1][2][3]

Interactions

PRKG1 has been shown to interact with:

• GTF2I,^[4]
• ITPR1,^[5]
• MRVI1,^[5][6]
• RGS2,^[7] and
• TNNT1.^[8]

References

1. Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Sep 1989). "Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat". FEBS Letters 255 (2): 321–9. doi:10.1016/0014-5793(89)81114-7. PMID 2792381.
2. Orstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T (April 1992). "Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell Genetics 59 (4): 270–3. doi:10.1159/000133267. PMID 1544322.
3. "Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I".
4. Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB (Aug 2002). "cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I". The Journal of Biological Chemistry 277 (35): 32003–14. doi:10.1074/jbc.M112332200. PMID 12082086.
5. Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174.
6. Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (Jun 2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". The Journal of Biological Chemistry 276 (26): 24153–9. doi:10.1074/jbc.M101530200. PMID 11309393.
7. Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME, Tang M, Wang G (Dec 2003). "Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure". Nature Medicine 9 (12): 1506–12. doi:10.1038/nm958. PMID 14608379.
8. Yuasa K, Michibata H, Omori K, Yanaka N (Dec 1999). "A novel interaction of cGMP-dependent protein kinase I with troponin T". The Journal of Biological Chemistry 274 (52): 37429–34. PMID 10601315.

Further reading

• Picciotto MR, Cohn JA, Bertuzzi G, Greengard P, Nairn AC (Jun 1992). "Phosphorylation of the cystic fibrosis transmembrane conductance regulator". The Journal of Biological Chemistry 267 (18): 12742–52. PMID 1377674.
• Thomas MK, Francis SH, Corbin JD (Sep 1990). "Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP". The Journal of Biological Chemistry 265 (25): 14971–8. PMID 2168396.
• Pöhler D, Butt E, Meissner J, Müller S, Lohse M, Walter U, Lohmann SM, Jarchau T (Nov 1995). "Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system". FEBS Letters 374 (3): 419–25. doi:10.1016/0014-5793(95)01168-E. PMID 7589584.
• Komalavilas P, Lincoln TM (Mar 1994). "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry 269 (12): 8701–7. PMID 8132598.
• Butt E, Abel K, Krieger M, Palm D, Hoppe V, Hoppe J, Walter U (May 1994). "cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets". The Journal of Biological Chemistry 269 (20): 14509–17. PMID 8182057.
• Suko J, Maurer-Fogy I, Plank B, Bertel O, Wyskovsky W, Hohenegger M, Hellmann G (Jan 1993). "Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase". Biochimica Et Biophysica Acta 1175 (2): 193–206. doi:10.1016/0167-4889(93)90023-I. PMID 8380342.
• Tamura N, Itoh H, Ogawa Y, Nakagawa O, Harada M, Chun TH, Suga S, Yoshimasa T, Nakao K (Mar 1996). "cDNA cloning and gene expression of human type Ialpha cGMP-dependent protein kinase". Hypertension 27 (3 Pt 2): 552–7. doi:10.1161/01.hyp.27.3.552. PMID 8613202.
• Salih E, Zhou HY, Glimcher MJ (Jul 1996). "Phosphorylation of purified bovine bone sialoprotein and osteopontin by protein kinases". The Journal of Biological Chemistry 271 (28): 16897–905. doi:10.1074/jbc.271.28.16897. PMID 8663267.
• Xing J, Ginty DD, Greenberg ME (Aug 1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science 273 (5277): 959–63. doi:10.1126/science.273.5277.959. PMID 8688081.
• Orstavik S, Natarajan V, Taskén K, Jahnsen T, Sandberg M (Jun 1997). "Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1)". Genomics 42 (2): 311–8. doi:10.1006/geno.1997.4743. PMID 9192852.
• Deak M, Clifton AD, Lucocq LM, Alessi DR (Aug 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". The EMBO Journal 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
• Du K, Montminy M (Dec 1998). "CREB is a regulatory target for the protein kinase Akt/PKB". The Journal of Biological Chemistry 273 (49): 32377–9. doi:10.1074/jbc.273.49.32377. PMID 9829964.
• Endo S, Suzuki M, Sumi M, Nairn AC, Morita R, Yamakawa K, Greengard P, Ito M (Mar 1999). "Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells". Proceedings of the National Academy of Sciences of the United States of America 96 (5): 2467–72. doi:10.1073/pnas.96.5.2467. PMC 26808. PMID 10051666.
• Wang X, Bruderer S, Rafi Z, Xue J, Milburn PJ, Krämer A, Robinson PJ (Aug 1999). "Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly". The EMBO Journal 18 (16): 4549–59. doi:10.1093/emboj/18.16.4549. PMC 1171529. PMID 10449420.
• Surks HK, Mochizuki N, Kasai Y, Georgescu SP, Tang KM, Ito M, Lincoln TM, Mendelsohn ME (Nov 1999). "Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha". Science 286 (5444): 1583–7. doi:10.1126/science.286.5444.1583. PMID 10567269.
• Yuasa K, Michibata H, Omori K, Yanaka N (Dec 1999). "A novel interaction of cGMP-dependent protein kinase I with troponin T". The Journal of Biological Chemistry 274 (52): 37429–34. doi:10.1074/jbc.274.52.37429. PMID 10601315.
• Yuasa K, Omori K, Yanaka N (Feb 2000). "Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha". The Journal of Biological Chemistry 275 (7): 4897–905. doi:10.1074/jbc.275.7.4897. PMID 10671526.
• Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD (Feb 2000). "Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle". The Journal of Biological Chemistry 275 (8): 5504–11. doi:10.1074/jbc.275.8.5504. PMID 10681529.