DCLK1

Doublecortin-like kinase 1
PDB rendering based on 1mfw.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1MFW​, 1MG4​, 1UF0​
Identifiers
Symbols	DCLK1 ; CL1; CLICK1; DCAMKL1; DCDC3A; DCLK
External IDs	OMIM: 604742 MGI: 1330861 HomoloGene: 130530 ChEMBL: 5683 GeneCards: DCLK1 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein kinase activity • protein serine/threonine kinase activity • receptor signaling protein activity • ATP binding Cellular component • intracellular • integral component of plasma membrane • neuronal postsynaptic density Biological process • neuron migration • protein phosphorylation • nervous system development • central nervous system development • response to virus • endosomal transport • central nervous system projection neuron axonogenesis • forebrain development • intracellular signal transduction • axon extension • dendrite morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9201	13175
Ensembl	ENSG00000133083	ENSMUSG00000027797
UniProt	O15075	Q9JLM8
RefSeq (mRNA)	NM_001195415	NM_001111051
RefSeq (protein)	NP_001182344	NP_001104521
Location (UCSC)	Chr 13: 35.77 – 36.13 Mb	Chr 3: 55.24 – 55.54 Mb
PubMed search

Serine/threonine-protein kinase DCLK1 is an enzyme that in humans is encoded by the DCLK1 gene.^[1][2][3]

References

1. Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T (Oct 1998). "Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin". J Hum Genet 43 (3): 169–77. doi:10.1007/s100380050063. PMID 9747029.
2. Sossey-Alaoui K, Srivastava AK (May 1999). "DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)". Genomics 56 (1): 121–6. doi:10.1006/geno.1998.5718. PMID 10036192.
3. "Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1".

Further reading

• Nagase T, Ishikawa K, Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Matsumoto N, Pilz DT, Ledbetter DH (1999). "Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS).". Genomics 56 (2): 179–83. doi:10.1006/geno.1998.5673. PMID 10051403.
• Lin PT, Gleeson JG, Corbo JC; et al. (2001). "DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization.". J. Neurosci. 20 (24): 9152–61. PMID 11124993.
• Burgess HA, Reiner O (2002). "Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities.". J. Biol. Chem. 277 (20): 17696–705. doi:10.1074/jbc.M111981200. PMID 11884394.
• Kim MH, Derewenda U, Devedjiev Y; et al. (2003). "Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase.". Acta Crystallogr. D Biol. Crystallogr. 59 (Pt 3): 502–5. doi:10.1107/S0907444903000027. PMID 12595708.
• Kim MH, Cierpicki T, Derewenda U; et al. (2003). "The DCX-domain tandems of doublecortin and doublecortin-like kinase.". Nat. Struct. Biol. 10 (5): 324–33. doi:10.1038/nsb918. PMID 12692530.
• Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes.". J. Biol. Chem. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. PMID 14613930.
• Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.