PSKH1

Protein serine kinase H1
Identifiers
Symbol	PSKH1
External IDs	OMIM: 177015 MGI: 3528383 HomoloGene: 48461 GeneCards: PSKH1 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • protein binding • ATP binding Cellular component • cellular_component • endoplasmic reticulum membrane • Golgi apparatus • microtubule organizing center • plasma membrane • nuclear speck Biological process • protein phosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5681	244631
Ensembl	ENSG00000159792	ENSMUSG00000048310
UniProt	P11801	Q91YA2
RefSeq (mRNA)	NM_006742	NM_173432
RefSeq (protein)	NP_006733	NP_775608
Location (UCSC)	Chr 16: 67.89 – 67.93 Mb	Chr 8: 105.9 – 105.93 Mb
PubMed search

Serine/threonine-protein kinase H1 is an enzyme that in humans is encoded by the PSKH1 gene.^[1][2]

Interactions

PSKH1 has been shown to interact with CDC6.^[3]

References

1. Larsen F, Solheim J, Kristensen T, Kolstø AB, Prydz H (Feb 1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum Mol Genet 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID 8268911.
2. "Entrez Gene: PSKH1 protein serine kinase H1".
3. Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K (Jan 1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization". EMBO J. 18 (2): 396–410. doi:10.1093/emboj/18.2.396. PMC 1171134. PMID 9889196.

Further reading

• Hanks SK (1987). "Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.". Proc. Natl. Acad. Sci. U.S.A. 84 (2): 388–92. doi:10.1073/pnas.84.2.388. PMC 304212. PMID 2948189.
• Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K (1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.". EMBO J. 18 (2): 396–410. doi:10.1093/emboj/18.2.396. PMC 1171134. PMID 9889196.
• Amarzguioui M, Brede G, Babaie E, Grotli M, Sproat B, Prydz H (2000). "Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymes.". Nucleic Acids Res. 28 (21): 4113–24. doi:10.1093/nar/28.21.4113. PMC 113158. PMID 11058107.
• Brede G, Solheim J, Tröen G, Prydz H (2001). "Characterization of PSKH1, a novel human protein serine kinase with centrosomal, golgi, and nuclear localization.". Genomics 70 (1): 82–92. doi:10.1006/geno.2000.6365. PMID 11087665.
• Brede G, Solheim J, Prydz H (2002). "PSKH1, a novel splice factor compartment-associated serine kinase.". Nucleic Acids Res. 30 (23): 5301–9. doi:10.1093/nar/gkf648. PMC 137962. PMID 12466556.
• Brede G, Solheim J, Stang E, Prydz H (2004). "Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus.". Exp. Cell Res. 291 (2): 299–312. doi:10.1016/j.yexcr.2003.07.009. PMID 14644153.