PCTK3

Cyclin-dependent kinase 18
Identifiers
Symbols	CDK18 ; PCTAIRE; PCTAIRE3; PCTK3
External IDs	OMIM: 169190 MGI: 97518 HomoloGene: 1949 ChEMBL: 5316 GeneCards: CDK18 Gene
EC number	2.7.11.22
Gene ontology Molecular function • cyclin-dependent protein serine/threonine kinase activity • protein binding • ATP binding Cellular component • cellular_component Biological process • protein phosphorylation • regulation of cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5129	18557
Ensembl	ENSG00000117266	ENSMUSG00000026437
UniProt	Q07002	Q04899
RefSeq (mRNA)	NM_002596	NM_008795
RefSeq (protein)	NP_002587	NP_032821
Location (UCSC)	Chr 1: 205.5 – 205.53 Mb	Chr 1: 132.11 – 132.14 Mb
PubMed search

Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the PCTK3 gene.^[1][2]

References

1. Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene 7 (11): 2249–58. PMID 1437147.
2. "Entrez Gene: PCTK3 PCTAIRE protein kinase 3".

Further reading

• Meyerson M, Enders GH, Wu CL, et al. (1992). "A family of human cdc2-related protein kinases.". EMBO J. 11 (8): 2909–17. PMC 556772. PMID 1639063.
• Okuda T, Valentine VA, Shapiro DN, Downing JR (1994). "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes.". Genomics 21 (1): 217–21. doi:10.1006/geno.1994.1245. PMID 8088790.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Herskovits AZ, Davies P (2004). "Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain.". Gene 328: 59–67. doi:10.1016/j.gene.2003.12.011. PMID 15019984.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport.". J. Cell. Sci. 118 (Pt 17): 3839–47. doi:10.1242/jcs.02496. PMID 16091426.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Herskovits AZ, Davies P (2006). "The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease.". Neurobiol. Dis. 23 (2): 398–408. doi:10.1016/j.nbd.2006.04.004. PMID 16766195.
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.