DAPK2

Death-associated protein kinase 2
PDB rendering based on 1wmk.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1WMK​, 1WRZ​, 1Z9X​, 1ZUZ​, 1ZWS​, 2A27​, 2A2A​, 2CKE​
Identifiers
Symbols	DAPK2 ; DRP-1; DRP1
External IDs	MGI: 1341297 HomoloGene: 74940 IUPHAR: 2003 ChEMBL: 3123 GeneCards: DAPK2 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • calmodulin-dependent protein kinase activity • protein binding • calmodulin binding • ATP binding • identical protein binding Cellular component • cytoplasm • cytoplasmic vesicle • autophagosome lumen Biological process • protein phosphorylation • apoptotic process • regulation of autophagy • intracellular signal transduction • regulation of apoptotic process • anoikis • protein autophosphorylation • regulation of intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23604	13143
Ensembl	ENSG00000035664	ENSMUSG00000032380
UniProt	Q9UIK4	Q8VDF3
RefSeq (mRNA)	NM_014326	NM_010019
RefSeq (protein)	NP_055141	NP_034149
Location (UCSC)	Chr 15: 63.91 – 64.07 Mb	Chr 9: 66.16 – 66.27 Mb
PubMed search

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.^[1][2]

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites.^[2] The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript. ^[3]

References

1. Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S (Jun 1999). "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity". Oncogene 18 (23): 3471–80. doi:10.1038/sj.onc.1202701. PMID 10376525.
2. "Entrez Gene: DAPK2 death-associated protein kinase 2".
3. "New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform".

Further reading

• Inbal B, Shani G, Cohen O; et al. (2000). "Death-Associated Protein Kinase-Related Protein 1, a Novel Serine/Threonine Kinase Involved in Apoptosis". Mol. Cell. Biol. 20 (3): 1044–54. doi:10.1128/MCB.20.3.1044-1054.2000. PMC 85221. PMID 10629061.
• Shani G, Henis-Korenblit S, Jona G; et al. (2001). "Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding". EMBO J. 20 (5): 1099–113. doi:10.1093/emboj/20.5.1099. PMC 145456. PMID 11230133.
• Wong TS, Chang HW, Tang KC; et al. (2002). "High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients". Clin. Cancer Res. 8 (2): 433–7. PMID 11839660.
• Chan MW, Chan LW, Tang NL; et al. (2002). "Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients". Clin. Cancer Res. 8 (2): 464–70. PMID 11839665.
• Inbal B, Bialik S, Sabanay I; et al. (2002). "DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death". J. Cell Biol. 157 (3): 455–68. doi:10.1083/jcb.200109094. PMC 2173279. PMID 11980920.
• Satoh A, Toyota M, Itoh F; et al. (2002). "DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers". Br. J. Cancer 86 (11): 1817–23. doi:10.1038/sj.bjc.6600319. PMC 2375414. PMID 12087472.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B; et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Rizzi M, Tschan MP, Britschgi C; et al. (2007). "The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells". J. Leukoc. Biol. 81 (6): 1599–608. doi:10.1189/jlb.0606400. PMID 17347302.