DAPK3

Death-associated protein kinase 3
PDB rendering based on 1yrp.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1YRP​, 2J90​, 3BHY​, 3BQR​
Identifiers
Symbols	DAPK3 ; DLK; ZIP; ZIPK
External IDs	OMIM: 603289 MGI: 1203520 HomoloGene: 20353 IUPHAR: 2004 ChEMBL: 2468 GeneCards: DAPK3 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • calmodulin-dependent protein kinase activity • protein binding • ATP binding • cAMP response element binding protein binding • Rho GTPase binding • identical protein binding • protein homodimerization activity • leucine zipper domain binding Cellular component • nucleus • cytoplasm • actin filament • PML body • membrane raft Biological process • cytokinesis • transcription, DNA-templated • regulation of transcription, DNA-templated • protein phosphorylation • apoptotic process • regulation of smooth muscle contraction • regulation of mitotic nuclear division • regulation of mitotic cell cycle • regulation of cell shape • regulation of autophagy • chromatin modification • negative regulation of translation • neuron differentiation • positive regulation of cell migration • intracellular signal transduction • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myosin II filament organization • protein autophosphorylation • regulation of focal adhesion assembly • cellular response to interferon-gamma • positive regulation of canonical Wnt signaling pathway • apoptotic signaling pathway • regulation of cell motility • regulation of actin cytoskeleton reorganization • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1613	13144
Ensembl	ENSG00000167657	ENSMUSG00000034974
UniProt	O43293	O54784
RefSeq (mRNA)	NM_001348	NM_001190473
RefSeq (protein)	NP_001339	NP_001177402
Location (UCSC)	Chr 19: 3.96 – 3.97 Mb	Chr 10: 81.18 – 81.19 Mb
PubMed search

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.^[1][2]

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.^[2]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.^[3]

Interactions

DAPK3 has been shown to interact with PAWR^[4] and Death associated protein 6.^[4]

References

1. Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Molecular and Cellular Biology 18 (3): 1642–51. doi:10.1128/mcb.18.3.1642. PMC 108879. PMID 9488481.
2. "Entrez Gene: DAPK3 death-associated protein kinase 3".
3. Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLoS Genetics 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
4. Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.

Further reading

• Saito T, Seki N, Ohira M, Hayashi A, Kozuma S, Hattori A, Hori T (1998). "Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization". Journal of Human Genetics 43 (3): 209–11. doi:10.1007/s100380050073. PMID 9747039.
• Murata-Hori M, Suizu F, Iwasaki T, Kikuchi A, Hosoya H (May 1999). "ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells". FEBS Letters 451 (1): 81–4. doi:10.1016/S0014-5793(99)00550-5. PMID 10356987.
• Page G, Lödige I, Kögel D, Scheidtmann KH (Nov 1999). "AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis". FEBS Letters 462 (1-2): 187–91. doi:10.1016/S0014-5793(99)01529-X. PMID 10580117.
• Page G, Kögel D, Rangnekar V, Scheidtmann KH (Dec 1999). "Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis". Oncogene 18 (51): 7265–73. doi:10.1038/sj.onc.1203170. PMID 10602480.
• Cariou B, Perdereau D, Cailliau K, Browaeys-Poly E, Béréziat V, Vasseur-Cognet M, Girard J, Burnol AF (Oct 2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta". Molecular and Cellular Biology 22 (20): 6959–70. doi:10.1128/MCB.22.20.6959-6970.2002. PMC 139806. PMID 12242277.
• Preuss U, Landsberg G, Scheidtmann KH (Feb 2003). "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase". Nucleic Acids Research 31 (3): 878–85. doi:10.1093/nar/gkg176. PMC 149197. PMID 12560483.
• Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.
• Burch LR, Scott M, Pohler E, Meek D, Hupp T (Mar 2004). "Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1". Journal of Molecular Biology 337 (1): 115–28. doi:10.1016/j.jmb.2003.10.081. PMID 15001356.
• Endo A, Surks HK, Mochizuki S, Mochizuki N, Mendelsohn ME (Oct 2004). "Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase". The Journal of Biological Chemistry 279 (40): 42055–61. doi:10.1074/jbc.M403676200. PMID 15292222.
• Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW (Feb 2005). "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB Journal 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID 15546961.
• Yu H, Jiang D, Guo Z, Saiyin H, Guo J, Wang X, Yu L (Jun 2005). "TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3". International Journal of Andrology 28 (3): 163–70. doi:10.1111/j.1365-2605.2005.00522.x. PMID 15910542.
• Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLoS Genetics 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
• Takamoto N, Komatsu S, Komaba S, Niiro N, Ikebe M (Dec 2006). "Novel ZIP kinase isoform lacks leucine zipper". Archives of Biochemistry and Biophysics 456 (2): 194–203. doi:10.1016/j.abb.2006.09.026. PMC 2758612. PMID 17126281.