PFTK1

Cyclin-dependent kinase 14
Identifiers
Symbols	CDK14 ; PFTAIRE1; PFTK1
External IDs	OMIM: 610679 MGI: 894318 HomoloGene: 7888 IUPHAR: 1967 ChEMBL: 6162 GeneCards: CDK14 Gene
EC number	2.7.11.22
Gene ontology Molecular function • cyclin-dependent protein serine/threonine kinase activity • protein binding • ATP binding • cyclin binding Cellular component • cytoplasmic cyclin-dependent protein kinase holoenzyme complex • nucleus • cytoplasm • cytosol • plasma membrane Biological process • G2/M transition of mitotic cell cycle • protein phosphorylation • Wnt signaling pathway • cell division • regulation of cell cycle • regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5218	18647
Ensembl	ENSG00000058091	ENSMUSG00000028926
UniProt	O94921	O35495
RefSeq (mRNA)	NM_001287135	NM_011074
RefSeq (protein)	NP_001274064	NP_035204
Location (UCSC)	Chr 7: 90.47 – 91.21 Mb	Chr 5: 4.8 – 5.42 Mb
PubMed search

Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the PFTK1 gene.^[1][2][3]

Interactions

PFTK1 has been shown to interact with SEPT8.^[4]

References

1. Lazzaro MA, Albert PR, Julien JP (Jul 1997). "A novel cdc2-related protein kinase expressed in the nervous system". J Neurochem 69 (1): 348–64. doi:10.1046/j.1471-4159.1997.69010348.x. PMID 9202329.
2. Yang T, Chen JY (Apr 2001). "Identification and cellular localization of human PFTAIRE1". Gene 267 (2): 165–72. doi:10.1016/S0378-1119(01)00391-2. PMID 11313143.
3. "Entrez Gene: PFTK1 PFTAIRE protein kinase 1".
4. Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (China) 34 (4): 520–5. ISSN 0582-9879. PMID 12098780.

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Yang T, Gao YK, Chen JY (2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1.". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34 (4): 520–5. PMID 12098780.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Gao Y, Jiang M, Yang T, et al. (2006). "A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins.". Cell Res. 16 (6): 539–47. doi:10.1038/sj.cr.7310071. PMID 16775625.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Shu F, Lv S, Qin Y, et al. (2007). "Functional characterization of human PFTK1 as a cyclin-dependent kinase.". Proc. Natl. Acad. Sci. U.S.A. 104 (22): 9248–53. doi:10.1073/pnas.0703327104. PMC 1890480. PMID 17517622.
• Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions.". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335. PMID 17567994.