FASTK

Fas-activated serine/threonine kinase
Identifiers
Symbols	FASTK ; FAST
External IDs	OMIM: 606965 MGI: 1913837 HomoloGene: 4884 GeneCards: FASTK Gene
EC number	2.7.11.8
Gene ontology Molecular function • protein serine/threonine kinase activity • protein binding • ATP binding • Fas-activated serine/threonine kinase activity Cellular component • mitochondrion Biological process • protein phosphorylation • regulation of RNA splicing • apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10922	66587
Ensembl	ENSG00000164896	ENSMUSG00000028959
UniProt	Q14296	Q9JIX9
RefSeq (mRNA)	NM_001258461	NM_023229
RefSeq (protein)	NP_001245390	NP_075718
Location (UCSC)	Chr 7: 151.08 – 151.08 Mb	Chr 5: 24.44 – 24.45 Mb
PubMed search

Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.^[1][2][3]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.^[3]

References

1. Tian Q, Taupin J, Elledge S, Robertson M, Anderson P (Sep 1995). "Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis". J Exp Med 182 (3): 865–74. doi:10.1084/jem.182.3.865. PMC 2192163. PMID 7544399.
2. Li W, Simarro M, Kedersha N, Anderson P (Dec 2004). "FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression". Mol Cell Biol 24 (24): 10718–32. doi:10.1128/MCB.24.24.10718-10732.2004. PMC 533970. PMID 15572676.
3. "Entrez Gene: FASTK Fas-activated serine/threonine kinase".

Further reading

• Auffray C, Behar G, Bois F; et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Li W, Kedersha N, Chen S; et al. (2004). "FAST is a BCL-X(L)-associated mitochondrial protein". Biochem. Biophys. Res. Commun. 318 (1): 95–102. doi:10.1016/j.bbrc.2004.03.188. PMID 15110758.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Oh JH, Yang JO, Hahn Y; et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Izquierdo JM, Valcárcel J (2007). "Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing". J. Biol. Chem. 282 (3): 1539–43. doi:10.1074/jbc.C600198200. PMID 17135269.
• Simarro M, Mauger D, Rhee K; et al. (2007). "Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing". Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11370–5. doi:10.1073/pnas.0704964104. PMC 2040905. PMID 17592127.