SNRK

SNF related kinase
Identifiers
Symbols	SNRK ; HSNFRK
External IDs	OMIM: 612760 MGI: 108104 HomoloGene: 9797 GeneCards: SNRK Gene
EC number	2.7.11.1
Gene ontology Molecular function • magnesium ion binding • protein serine/threonine kinase activity • ATP binding Cellular component • nucleus • cytoplasm Biological process • protein phosphorylation • myeloid cell differentiation • intracellular signal transduction Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54861	20623
Ensembl	ENSG00000163788	ENSMUSG00000038145
UniProt	Q9NRH2	Q8VDU5
RefSeq (mRNA)	NM_001100594	NM_001164572
RefSeq (protein)	NP_001094064	NP_001158044
Location (UCSC)	Chr 3: 43.29 – 43.42 Mb	Chr 9: 122.12 – 122.17 Mb
PubMed search

SNF-related serine/threonine-protein kinase is an enzyme that in humans is encoded by the SNRK gene.^[1][2][3]

References

1. Becker W, Heukelbach J, Kentrup H, Joost HG (Jul 1996). "Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases". Eur J Biochem 235 (3): 736–43. doi:10.1111/j.1432-1033.1996.00736.x. PMID 8654423.
2. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
3. "Entrez Gene: SNRK SNF related kinase".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Iacobelli M, Wachsman W, McGuire KL (2000). "Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein". J. Immunol. 165 (2): 860–8. doi:10.4049/jimmunol.165.2.860. PMID 10878360.
• Yoshida K, Yamada M, Nishio C, Konishi A, Hatanaka H (2000). "SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neurons". Brain Res. 873 (2): 274–82. doi:10.1016/S0006-8993(00)02548-8. PMID 10930554.
• Bower KE, Zeller RW, Wachsman W, Martinez T, McGuire KL (2002). "Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions". J. Biol. Chem. 277 (38): 34967–77. doi:10.1074/jbc.M205048200. PMID 12087103.
• Kertesz N, Samson J, Debacker C, Wu H, Labastie MC (2003). "Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases". Gene 294 (1–2): 13–24. doi:10.1016/S0378-1119(02)00829-6. PMID 12234663.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR (2005). "Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate". FEBS Lett. 579 (6): 1417–23. doi:10.1016/j.febslet.2005.01.042. PMID 15733851.