SNF1LK2

Salt-inducible kinase 2
Identifiers
Symbols	SIK2 ; LOH11CR1I; QIK; SIK-2; SNF1LK2
External IDs	OMIM: 608973 MGI: 2445031 HomoloGene: 22875 ChEMBL: 5699 GeneCards: SIK2 Gene
EC number	2.7.11.1
Gene ontology Molecular function • magnesium ion binding • protein serine/threonine kinase activity • protein binding • ATP binding Cellular component • nucleus • cytoplasm Biological process • protein phosphorylation • insulin receptor signaling pathway • intracellular signal transduction • regulation of insulin receptor signaling pathway • protein autophosphorylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23235	235344
Ensembl	ENSG00000170145	ENSMUSG00000037112
UniProt	Q9H0K1	Q8CFH6
RefSeq (mRNA)	NM_015191	NM_178710
RefSeq (protein)	NP_056006	NP_848825
Location (UCSC)	Chr 11: 111.6 – 111.73 Mb	Chr 9: 50.89 – 51.01 Mb
PubMed search

Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene.^[1][2]

Interactions

SNF1LK2 has been shown to interact with CRTC2.^[3]

References

1. Katoh M, Katoh M (May 2004). "Identification and characterization of human FOXN5 and rat Foxn5 genes in silico". International Journal of Oncology 24 (5): 1339–44. doi:10.3892/ijo.24.5.1339. PMID 15067358.
2. "Entrez Gene: SNF1LK2 SNF1-like kinase 2".
3. Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M (May 2003). "Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2". The Journal of Biological Chemistry 278 (20): 18440–7. doi:10.1074/jbc.M211770200. PMID 12624099.
• Katoh M, Katoh M (Nov 2003). "Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats". International Journal of Oncology 23 (5): 1471–6. doi:10.3892/ijo.23.5.1471. PMID 14532992.
• Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (Feb 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
• Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
• Katoh Y, Takemori H, Min L, Muraoka M, Doi J, Horike N, Okamoto M (Nov 2004). "Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm". European Journal of Biochemistry / FEBS 271 (21): 4307–19. doi:10.1111/j.1432-1033.2004.04372.x. PMID 15511237.