Cyclin-dependent kinase 7

Cyclin-dependent kinase 7
PDB rendering based on 1ua2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1LG3​, 1PA8​, 1UA2​, 2HIC​
Identifiers
Symbols	CDK7 ; CAK1; CDKN7; HCAK; MO15; STK1; p39MO15
External IDs	OMIM: 601955 MGI: 102956 HomoloGene: 1363 ChEMBL: 3055 GeneCards: CDK7 Gene
EC number	2.7.11.22, 2.7.11.23
Gene ontology Molecular function • transcription coactivator activity • protein kinase activity • cyclin-dependent protein serine/threonine kinase activity • protein binding • ATP binding • protein C-terminus binding • DNA-dependent ATPase activity • RNA polymerase II carboxy-terminal domain kinase activity • androgen receptor binding Cellular component • nucleus • nucleoplasm • holo TFIIH complex • cytoplasm • mitochondrion • perinuclear region of cytoplasm Biological process • regulation of cyclin-dependent protein serine/threonine kinase activity • G1/S transition of mitotic cell cycle • G2/M transition of mitotic cell cycle • mitotic cell cycle • nucleotide-excision repair, DNA damage removal • DNA repair • transcription-coupled nucleotide-excision repair • nucleotide-excision repair • transcription from RNA polymerase I promoter • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase I promoter • termination of RNA polymerase I transcription • transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • 7-methylguanosine mRNA capping • protein phosphorylation • cell cycle arrest • cell proliferation • gene expression • viral process • androgen receptor signaling pathway • regulation of gene expression, epigenetic • negative regulation of gene expression, epigenetic • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of viral transcription • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1022	12572
Ensembl	ENSG00000134058	ENSMUSG00000069089
UniProt	P50613	Q03147
RefSeq (mRNA)	NM_001799	NM_009874
RefSeq (protein)	NP_001790	NP_034004
Location (UCSC)	Chr 5: 69.23 – 69.28 Mb	Chr 13: 100.7 – 100.73 Mb
PubMed search

Cell division protein kinase 7 is an enzyme that in humans is encoded by the CDK7 gene.^[1]

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.^[2]

Interactions

Cyclin-dependent kinase 7 has been shown to interact with:

• Androgen receptor,^[3]
• Cyclin H,^[4][5][6]
• GTF2H1,^[7][4][8]
• MNAT1,^[4][9]
• P53,^[10][11]
• SUPT5H,^[6] and
• XPB.^[12][7][4]

See also

• Cyclin-dependent kinase
• CDK7 pathway

References

1. Fisher RP, Morgan DO (Aug 1994). "A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase". Cell 78 (4): 713–24. doi:10.1016/0092-8674(94)90535-5. PMID 8069918.
2. "Entrez Gene: CDK7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)".
3. Lee DK, Duan HO, Chang C (Mar 2000). "From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator". The Journal of Biological Chemistry 275 (13): 9308–13. doi:10.1074/jbc.275.13.9308. PMID 10734072.
4. Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (Dec 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Research 55 (24): 6058–62. PMID 8521393.
5. Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA (Sep 1994). "A cyclin associated with the CDK-activating kinase MO15". Nature 371 (6494): 254–7. doi:10.1038/371254a0. PMID 8078587.
6. Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA (Sep 2000). "CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA". Molecular and Cellular Biology 20 (18): 6958–69. doi:10.1128/mcb.20.18.6958-6969.2000. PMC 88771. PMID 10958691.
7. Rossignol M, Kolb-Cheynel I, Egly JM (Apr 1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". The EMBO Journal 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. PMC 1169767. PMID 9130708.
8. Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (Mar 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature 374 (6519): 283–7. doi:10.1038/374283a0. PMID 7533895.
9. Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA, Barnes CJ, Kumar R (Mar 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". The Journal of Biological Chemistry 278 (13): 11676–85. doi:10.1074/jbc.M209570200. PMID 12527756.
10. Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ (Dec 1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner". Molecular and Cellular Biology 17 (12): 7220–9. PMC 232579. PMID 9372954.
11. Schneider E, Montenarh M, Wagner P (Nov 1998). "Regulation of CAK kinase activity by p53". Oncogene 17 (21): 2733–41. doi:10.1038/sj.onc.1202504. PMID 9840937.
12. Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (Jul 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nature Genetics 36 (7): 714–9. doi:10.1038/ng1387. PMID 15220921.

Further reading

• Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". Journal of Biomedical Science 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510.
• Yankulov K, Bentley D (Jun 1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Current Biology 8 (13): R447–9. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670.
• Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (Mar 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature 374 (6519): 283–7. doi:10.1038/374283a0. PMID 7533895.
• Aprelikova O, Xiong Y, Liu ET (Aug 1995). "Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase". The Journal of Biological Chemistry 270 (31): 18195–7. doi:10.1074/jbc.270.31.18195. PMID 7629134.
• Serizawa H, Mäkelä TP, Conaway JW, Conaway RC, Weinberg RA, Young RA (Mar 1995). "Association of Cdk-activating kinase subunits with transcription factor TFIIH". Nature 374 (6519): 280–2. doi:10.1038/374280a0. PMID 7885450.
• Tassan JP, Schultz SJ, Bartek J, Nigg EA (Oct 1994). "Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)". The Journal of Cell Biology 127 (2): 467–78. doi:10.1083/jcb.127.2.467. PMC 2120215. PMID 7929589.
• Darbon JM, Devault A, Taviaux S, Fesquet D, Martinez AM, Galas S, Cavadore JC, Dorée M, Blanchard JM (Nov 1994). "Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase". Oncogene 9 (11): 3127–38. PMID 7936635.
• Williams RT, Wu L, Carbonaro-Hall DA, Hall FL (Oct 1994). "Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells". Archives of Biochemistry and Biophysics 314 (1): 99–106. doi:10.1006/abbi.1994.1416. PMID 7944411.
• Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA (Sep 1994). "A cyclin associated with the CDK-activating kinase MO15". Nature 371 (6494): 254–7. doi:10.1038/371254a0. PMID 8078587.
• Levedakou EN, He M, Baptist EW, Craven RJ, Cance WG, Welcsh PL, Simmons A, Naylor SL, Leach RJ, Lewis TB (Jul 1994). "Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern". Oncogene 9 (7): 1977–88. PMID 8208544.
• Wu L, Yee A, Liu L, Carbonaro-Hall D, Venkatesan N, Tolo VT, Hall FL (Jul 1994). "Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase". Oncogene 9 (7): 2089–96. PMID 8208556.
• Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (Dec 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Research 55 (24): 6058–62. PMID 8521393.
• Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (May 1996). "Three functional classes of transcriptional activation domain". Molecular and Cellular Biology 16 (5): 2044–55. PMC 231191. PMID 8628270.
• Bartkova J, Zemanova M, Bartek J (Jun 1996). "Expression of CDK7/CAK in normal and tumor cells of diverse histogenesis, cell-cycle position and differentiation". International Journal of Cancer. Journal International Du Cancer 66 (6): 732–7. doi:10.1002/(SICI)1097-0215(19960611)66:6<732::AID-IJC4>3.0.CO;2-0. PMID 8647641.
• Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J, Pan ZQ (Jun 1996). "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH". Proceedings of the National Academy of Sciences of the United States of America 93 (13): 6482–7. doi:10.1073/pnas.93.13.6482. PMC 39049. PMID 8692841.
• Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (Jun 1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proceedings of the National Academy of Sciences of the United States of America 93 (13): 6488–93. doi:10.1073/pnas.93.13.6488. PMC 39050. PMID 8692842.
• Zhou Q, Sharp PA (Oct 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science 274 (5287): 605–10. doi:10.1126/science.274.5287.605. PMID 8849451.
• Parada CA, Roeder RG (Nov 1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature 384 (6607): 375–8. doi:10.1038/384375a0. PMID 8934526.
• García-Martínez LF, Ivanov D, Gaynor RB (Mar 1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". The Journal of Biological Chemistry 272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID 9054383.

External links

• CDK7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• CDK7 human gene location in the UCSC Genome Browser.
• CDK7 human gene details in the UCSC Genome Browser.