CUL7

Cullin 7
PDB rendering based on 2jng.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2JNG​
Identifiers
Symbols	CUL7 ; 3M1; KIAA0076; dJ20C7.5
External IDs	OMIM: 609577 MGI: 1913765 HomoloGene: 56683 GeneCards: CUL7 Gene
Gene ontology Molecular function • protein binding • ubiquitin protein ligase binding Cellular component • nucleus • nucleoplasm • anaphase-promoting complex • cytoplasm • Golgi apparatus • centrosome • cytosol • Cul7-RING ubiquitin ligase complex • perinuclear region of cytoplasm • 3M complex Biological process • microtubule cytoskeleton organization • mitotic cytokinesis • vasculogenesis • epithelial to mesenchymal transition • placenta development • proteolysis • ubiquitin-dependent protein catabolic process • Golgi organization • regulation of mitotic nuclear division • viral process • protein ubiquitination • endoplasmic reticulum unfolded protein response • IRE1-mediated unfolded protein response • cellular protein metabolic process • positive regulation of dendrite morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9820	66515
Ensembl	ENSG00000044090	ENSMUSG00000038545
UniProt	Q14999	Q8VE73
RefSeq (mRNA)	NM_001168370	NM_025611
RefSeq (protein)	NP_001161842	NP_079887
Location (UCSC)	Chr 6: 43.04 – 43.05 Mb	Chr 17: 46.65 – 46.66 Mb
PubMed search

Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.^[1][2][3]

Clinical significance

It is associated with 3-M syndrome.

Interactions

CUL7 has been shown to interact with RBX1.^[1]

References

1. Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc Natl Acad Sci U S A 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
2. Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis". Proc Natl Acad Sci U S A 100 (17): 9855–60. doi:10.1073/pnas.1733908100. PMC 187864. PMID 12904573.
3. "Entrez Gene: CUL7 cullin 7".

Further reading

• Kim SS, Shago M, Kaustov L; et al. (2007). "CUL7 is a novel antiapoptotic oncogene.". Cancer Res. 67 (20): 9616–22. doi:10.1158/0008-5472.CAN-07-0644. PMID 17942889.
• Jung P, Verdoodt B, Bailey A; et al. (2007). "Induction of cullin 7 by DNA damage attenuates p53 function.". Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11388–93. doi:10.1073/pnas.0609467104. PMC 2040908. PMID 17586686.
• Skaar JR, Florens L, Tsutsumi T; et al. (2007). "PARC and CUL7 form atypical cullin RING ligase complexes.". Cancer Res. 67 (5): 2006–14. doi:10.1158/0008-5472.CAN-06-3241. PMID 17332328.
• Kaustov L, Lukin J, Lemak A; et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53.". J. Biol. Chem. 282 (15): 11300–7. doi:10.1074/jbc.M611297200. PMID 17298945.
• Kasper JS, Arai T, DeCaprio JA (2006). "A novel p53-binding domain in CUL7.". Biochem. Biophys. Res. Commun. 348 (1): 132–8. doi:10.1016/j.bbrc.2006.07.013. PMID 16875676.
• Andrews P, He YJ, Xiong Y (2006). "Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function.". Oncogene 25 (33): 4534–48. doi:10.1038/sj.onc.1209490. PMID 16547496.
• Huber C, Dias-Santagata D, Glaser A; et al. (2005). "Identification of mutations in CUL7 in 3-M syndrome.". Nat. Genet. 37 (10): 1119–24. doi:10.1038/ng1628. PMID 16142236.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Winston JT, Koepp DM, Zhu C; et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
• Nomura N, Nagase T, Miyajima N; et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.

External links

• GeneReviews/NIH/NCBI/UW entry on 3-M syndrome
• OMIM entries entry on 3-M syndrome