MAPK7

Mitogen-activated protein kinase 7
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MAPK7 ; BMK1; ERK4; ERK5; PRKM7
External IDs OMIM: 602521 MGI: 1346347 HomoloGene: 2060 ChEMBL: 5332 GeneCards: MAPK7 Gene
EC number 2.7.11.24
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5598 23939
Ensembl ENSG00000166484 ENSMUSG00000001034
UniProt Q13164 Q9WVS8
RefSeq (mRNA) NM_002749 NM_001291033
RefSeq (protein) NP_002740 NP_001277962
Location (UCSC) Chr 17:
19.38 – 19.38 Mb
Chr 11:
61.49 – 61.49 Mb
PubMed search

Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene.[1][2]

Function

MAPK7 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor tyrosine kinases, and G protein-coupled receptors. In response to extracellular signals, this kinase translocates to the cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.[3]

MAPK7 is also critical for cardiovascular development [4] and is essential for endothelial cell function.[5][6]

Interactions

MAPK7 has been shown to interact with:

References

  1. Purandare SM, Lee JD, Patel PI (March 1999). "Assignment of big MAP kinase (PRKM7) to human chromosome 17 band p11.2 with somatic cell hybrids". Cytogenet. Cell Genet. 83 (3-4): 258–9. doi:10.1159/000015199. PMID 10072598.
  2. 1 2 Zhou G, Bao ZQ, Dixon JE (Jun 1995). "Components of a new human protein kinase signal transduction pathway". J. Biol. Chem. 270 (21): 12665–9. doi:10.1074/jbc.270.21.12665. PMID 7759517.
  3. "Entrez Gene: MAPK7 mitogen-activated protein kinase 7".
  4. Hayashi M, Lee JD (Oct 2004). "Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice". J. Mol. Med. 82 (12): 800–8. doi:10.1007/s00109-004-0602-8. PMID 15517128.
  5. Roberts OL, Holmes K, Müller J, Cross DA, Cross MJ (Dec 2009). "ERK5 and the regulation of endothelial cell function". Biochem. Soc. Trans. 37 (Pt 6): 1254–9. doi:10.1042/BST0371254. PMID 19909257.
  6. Roberts OL, Holmes K, Müller J, Cross DA, Cross MJ (Sep 2010). "ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells". J. Cell. Sci. 123 (Pt 18): 3189–200. doi:10.1242/jcs.072801. PMID 20736307.
  7. English JM, Pearson G, Hockenberry T, Shivakumar L, White MA, Cobb MH (Oct 1999). "Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control". J. Biol. Chem. 274 (44): 31588–92. doi:10.1074/jbc.274.44.31588. PMID 10531364.
  8. Cameron SJ, Malik S, Akaike M, Lerner-Marmarosh N, Yan C, Lee JD, Abe J, Yang J (May 2003). "Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation". J. Biol. Chem. 278 (20): 18682–8. doi:10.1074/jbc.M213283200. PMID 12637502.
  9. 1 2 Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Res. 26 (20): 4771–7. doi:10.1093/nar/26.20.4771. PMC 147902. PMID 9753748.
  10. Buschbeck M, Eickhoff J, Sommer MN, Ullrich A (Aug 2002). "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway". J. Biol. Chem. 277 (33): 29503–9. doi:10.1074/jbc.M202149200. PMID 12042304.
  11. Hayashi M, Tapping RI, Chao TH, Lo JF, King CC, Yang Y, Lee JD (Mar 2001). "BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase". J. Biol. Chem. 276 (12): 8631–4. doi:10.1074/jbc.C000838200. PMID 11254654.
  12. Zheng Q, Yin G, Yan C, Cavet M, Berk BC (Mar 2004). "14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function". J. Biol. Chem. 279 (10): 8787–91. doi:10.1074/jbc.M310212200. PMID 14679215.

Further reading

External links

This article is issued from Wikipedia - version of the Tuesday, January 12, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.