MKNK1

MAP kinase interacting serine/threonine kinase 1
PDB rendering based on 2hw6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2HW6​, 2Y9Q​
Identifiers
Symbols	MKNK1 ; MNK1
External IDs	OMIM: 606724 MGI: 894316 HomoloGene: 37838 ChEMBL: 4718 GeneCards: MKNK1 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • calmodulin-dependent protein kinase activity • protein binding • calmodulin binding • ATP binding • calcium-dependent protein serine/threonine kinase activity Cellular component • nucleus • cytoplasm • cytosol Biological process • regulation of translation • protein phosphorylation • fibroblast growth factor receptor signaling pathway • peptidyl-serine phosphorylation • intracellular signal transduction • protein autophosphorylation • extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8569	17346
Ensembl	ENSG00000079277	ENSMUSG00000028708
UniProt	Q9BUB5	O08605
RefSeq (mRNA)	NM_001135553	NM_001285487
RefSeq (protein)	NP_001129025	NP_001272416
Location (UCSC)	Chr 1: 46.56 – 46.62 Mb	Chr 4: 115.84 – 115.88 Mb
PubMed search

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.^[1][2]

Interactions

MKNK1 has been shown to interact with MAPK1^[3] and Eukaryotic translation initiation factor 4 gamma.^[4]

References

1. Fukunaga R, Hunter T (Jun 1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMC 1169795. PMID 9155018.
2. "Entrez Gene: MKNK1 MAP kinase interacting serine/threonine kinase 1".
3. Waskiewicz, A J; Flynn A; Proud C G; Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. (ENGLAND) 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. ISSN 0261-4189. PMC 1169794. PMID 9155017.
4. Pyronnet, S; Imataka H; Gingras A C; Fukunaga R; Hunter T; Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. (ENGLAND) 18 (1): 270–9. doi:10.1093/emboj/18.1.270. ISSN 0261-4189. PMC 1171121. PMID 9878069.

Further reading

• de Carvalho MG, McCormack AL, Olson E, et al. (1996). "Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes.". J. Biol. Chem. 271 (12): 6987–97. doi:10.1074/jbc.271.12.6987. PMID 8636128.
• Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.". EMBO J. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. PMC 1169794. PMID 9155017.
• Börsch-Haubold AG, Bartoli F, Asselin J, et al. (1998). "Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells.". J. Biol. Chem. 273 (8): 4449–58. doi:10.1074/jbc.273.8.4449. PMID 9468497.
• Pyronnet S, Imataka H, Gingras AC, et al. (1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.". EMBO J. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. PMC 1171121. PMID 9878069.
• Waskiewicz AJ, Johnson JC, Penn B, et al. (1999). "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo.". Mol. Cell. Biol. 19 (3): 1871–80. PMC 83980. PMID 10022874.
• Cuesta R, Laroia G, Schneider RJ (2000). "Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes.". Genes Dev. 14 (12): 1460–70. PMC 316692. PMID 10859165.
• Hefner Y, Borsch-Haubold AG, Murakami M, et al. (2001). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.". J. Biol. Chem. 275 (48): 37542–51. doi:10.1074/jbc.M003395200. PMID 10978317.
• Scheper GC, Morrice NA, Kleijn M, Proud CG (2001). "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.". Mol. Cell. Biol. 21 (3): 743–54. doi:10.1128/MCB.21.3.743-754.2001. PMC 86666. PMID 11154262.
• Knauf U, Tschopp C, Gram H (2001). "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.". Mol. Cell. Biol. 21 (16): 5500–11. doi:10.1128/MCB.21.16.5500-5511.2001. PMC 87272. PMID 11463832.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Cuesta R, Xi Q, Schneider RJ (2004). "Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein.". J. Virol. 78 (14): 7707–16. doi:10.1128/JVI.78.14.7707-7716.2004. PMC 434077. PMID 15220445.
• Orton KC, Ling J, Waskiewicz AJ, et al. (2004). "Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.". J. Biol. Chem. 279 (37): 38649–57. doi:10.1074/jbc.M407337200. PMID 15234964.
• O'Loghlen A, González VM, Piñeiro D, et al. (2004). "Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1.". Exp. Cell Res. 299 (2): 343–55. doi:10.1016/j.yexcr.2004.06.006. PMID 15350534.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Worch J, Tickenbrock L, Schwäble J, et al. (2005). "The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells.". Oncogene 23 (57): 9162–72. doi:10.1038/sj.onc.1208164. PMID 15516979.
• Grund EM, Spyropoulos DD, Watson DK, Muise-Helmericks RC (2005). "Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells.". J. Biol. Chem. 280 (6): 4772–8. doi:10.1074/jbc.M408356200. PMID 15563472.
• O'Loghlen A, González VM, Salinas M, Martín ME (2005). "Suppression of human Mnk1 by small interfering RNA increases the eukaryotic initiation factor 4F activity in HEK293T cells.". FEBS Lett. 578 (1-2): 31–5. doi:10.1016/j.febslet.2004.10.063. PMID 15581611.