CDK12

Cyclin-dependent kinase 12
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4CXA​, 4NST​, 4UN0​
Identifiers
Symbols	CDK12 ; CRK7; CRKR; CRKRS
External IDs	OMIM: 615514 MGI: 1098802 HomoloGene: 128632 GeneCards: CDK12 Gene
EC number	2.7.11.22, 2.7.11.23
Gene ontology Molecular function • protein kinase activity • cyclin-dependent protein serine/threonine kinase activity • protein binding • ATP binding • RNA polymerase II carboxy-terminal domain kinase activity • cyclin binding Cellular component • cyclin K-CDK12 complex • nucleus • nucleoplasm • nucleolus • nuclear speck • nuclear cyclin-dependent protein kinase holoenzyme complex Biological process • mRNA processing • RNA splicing • regulation of MAP kinase activity • regulation of RNA splicing • protein autophosphorylation • regulation of cell cycle • phosphorylation of RNA polymerase II C-terminal domain Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51755	69131
Ensembl	ENSG00000167258	ENSMUSG00000003119
UniProt	Q9NYV4	Q14AX6
RefSeq (mRNA)	NM_015083	NM_001109626
RefSeq (protein)	NP_055898	NP_001103096
Location (UCSC)	Chr 17: 39.46 – 39.56 Mb	Chr 11: 98.2 – 98.28 Mb
PubMed search

CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene.^[1][2][3] This enzyme is a member of cyclin-dependent kinase protein family.

References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
2. Ko TK, Kelly E, Pines J (Oct 2001). "CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles". J Cell Sci 114 (Pt 14): 2591–603. PMID 11683387.
3. "Entrez Gene: CDK12 cyclin-dependent kinase 12".

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Wissing J, Jänsch L, Nimtz M; et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.