MKNK2

MAP kinase interacting serine/threonine kinase 2
PDB rendering based on 2ac3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2AC3​, 2AC5​, 2HW7​
Identifiers
Symbols	MKNK2 ; GPRK7; MNK2
External IDs	OMIM: 605069 MGI: 894279 HomoloGene: 49674 IUPHAR: 2105 ChEMBL: 4204 GeneCards: MKNK2 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • calmodulin-dependent protein kinase activity • protein binding • calmodulin binding • ATP binding • calcium-dependent protein serine/threonine kinase activity • metal ion binding Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • PML body Biological process • regulation of translation • protein phosphorylation • apoptotic process • cell surface receptor signaling pathway • peptidyl-serine phosphorylation • hemopoiesis • intracellular signal transduction • protein autophosphorylation • cellular response to arsenic-containing substance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2872	17347
Ensembl	ENSG00000099875	ENSMUSG00000020190
UniProt	Q9HBH9	Q8CDB0
RefSeq (mRNA)	NM_017572	NM_021462
RefSeq (protein)	NP_060042	NP_067437
Location (UCSC)	Chr 19: 2.04 – 2.05 Mb	Chr 10: 80.67 – 80.68 Mb
PubMed search

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.^[1][2]

Interactions

MKNK2 has been shown to interact with MAPK1^[3][4] and Eukaryotic translation initiation factor 4 gamma.^[3]

References

1. Slentz-Kesler K, Moore JT, Lombard M, Zhang J, Hollingsworth R, Weiner MP (Oct 2000). "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta". Genomics 69 (1): 63–71. doi:10.1006/geno.2000.6299. PMID 11013076.
2. "Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2".
3. Scheper, Gert C; Parra Josep L; Wilson Mary; Van Kollenburg Barbara; Vertegaal Alfred C O; Han Ze-Guang; Proud Christopher G (Aug 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Mol. Cell. Biol. (United States) 23 (16): 5692–705. doi:10.1128/MCB.23.16.5692-5705.2003. ISSN 0270-7306. PMC 166352. PMID 12897141.
4. Waskiewicz, A J; Flynn A; Proud C G; Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. (ENGLAND) 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. ISSN 0261-4189. PMC 1169794. PMID 9155017.

Further reading

• Haribabu B, Snyderman R (1993). "Identification of additional members of human G-protein-coupled receptor kinase multigene family.". Proc. Natl. Acad. Sci. U.S.A. 90 (20): 9398–402. doi:10.1073/pnas.90.20.9398. PMC 47575. PMID 8415712.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.". EMBO J. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. PMC 1169794. PMID 9155017.
• Scheper GC, Morrice NA, Kleijn M, Proud CG (2001). "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.". Mol. Cell. Biol. 21 (3): 743–54. doi:10.1128/MCB.21.3.743-754.2001. PMC 86666. PMID 11154262.
• Knauf U, Tschopp C, Gram H (2001). "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.". Mol. Cell. Biol. 21 (16): 5500–11. doi:10.1128/MCB.21.16.5500-5511.2001. PMC 87272. PMID 11463832.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scheper GC, Parra JL, Wilson M, et al. (2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.". Mol. Cell. Biol. 23 (16): 5692–705. doi:10.1128/MCB.23.16.5692-5705.2003. PMC 166352. PMID 12897141.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yoshizuka N, Yoshizuka-Chadani Y, Krishnan V, Zeichner SL (2005). "Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway.". J. Virol. 79 (17): 11366–81. doi:10.1128/JVI.79.17.11366-11381.2005. PMC 1193619. PMID 16103188.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Jauch R, Jäkel S, Netter C, et al. (2006). "Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.". Structure 13 (10): 1559–68. doi:10.1016/j.str.2005.07.013. PMID 16216586.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wang P, Wang X, Wang F, et al. (2006). "Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex.". Sci. China, C, Life Sci. 49 (3): 265–73. doi:10.1007/s11427-006-0265-5. PMID 16856496.