EIF2AK4

Eukaryotic translation initiation factor 2 alpha kinase 4
Identifiers
Symbols	EIF2AK4 ; GCN2; PVOD2
External IDs	OMIM: 609280 MGI: 1353427 HomoloGene: 40891 ChEMBL: 5358 GeneCards: EIF2AK4 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • eukaryotic translation initiation factor 2alpha kinase activity • ATP binding Cellular component • cytosolic ribosome Biological process • regulation of translational initiation • protein phosphorylation • cellular response to starvation • regulation of translational initiation by eIF2 alpha phosphorylation • negative regulation of translation • endoplasmic reticulum unfolded protein response Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	440275	27103
Ensembl	ENSG00000128829	ENSMUSG00000005102
UniProt	Q9P2K8	Q9QZ05
RefSeq (mRNA)	NM_001013703	NM_001177806
RefSeq (protein)	NP_001013725	NP_001171277
Location (UCSC)	Chr 15: 39.93 – 40.04 Mb	Chr 2: 118.39 – 118.48 Mb
PubMed search

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.^[1][2]

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM]^[2]

See also

• Gcn2

References

1. Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase". Eur J Biochem 265 (2): 754–62. doi:10.1046/j.1432-1327.1999.00780.x. PMID 10504407.
2. "Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4".

Further reading

• Nagase T, Kikuno R, Ishikawa KI; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark AG, Glanowski S, Nielsen R; et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.". Science 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B; et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Wissing J, Jänsch L, Nimtz M; et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.