LATS2

Large tumor suppressor kinase 2
Identifiers
Symbols	LATS2 ; KPM
External IDs	OMIM: 604861 MGI: 1354386 HomoloGene: 56678 ChEMBL: 5907 GeneCards: LATS2 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • protein binding • ATP binding • metal ion binding Cellular component • spindle pole • nucleus • cytoplasm • microtubule organizing center • cytosol Biological process • G1/S transition of mitotic cell cycle • protein phosphorylation • mitotic nuclear division • hormone-mediated signaling pathway • peptidyl-serine phosphorylation • keratinocyte differentiation • cellular protein localization • hippo signaling • intracellular signal transduction • positive regulation of apoptotic process • negative regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of organ growth • cell division • negative regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26524	50523
Ensembl	ENSG00000150457	ENSMUSG00000021959
UniProt	Q9NRM7	Q7TSJ6
RefSeq (mRNA)	NM_014572	NM_015771
RefSeq (protein)	NP_055387	NP_056586
Location (UCSC)	Chr 13: 20.97 – 21.06 Mb	Chr 14: 57.64 – 57.76 Mb
PubMed search

Serine/threonine-protein kinase LATS2 is an enzyme that in humans is encoded by the LATS2 gene.^[1][2]

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.^[2]

References

1. Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics 63 (2): 263–70. doi:10.1006/geno.1999.6065. PMID 10673337.
2. "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)".

Further reading

• Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T (2000). "Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor.". Oncogene 19 (27): 3101–9. doi:10.1038/sj.onc.1203659. PMID 10871863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Li Y, Pei J, Xia H, et al. (2003). "Lats2, a putative tumor suppressor, inhibits G1/S transition.". Oncogene 22 (28): 4398–405. doi:10.1038/sj.onc.1206603. PMID 12853976.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Powzaniuk M, McElwee-Witmer S, Vogel RL, et al. (2005). "The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor.". Mol. Endocrinol. 18 (8): 2011–23. doi:10.1210/me.2004-0065. PMID 15131260.
• Toji S, Yabuta N, Hosomi T, et al. (2005). "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.". Genes Cells 9 (5): 383–97. doi:10.1111/j.1356-9597.2004.00732.x. PMID 15147269.
• Ke H, Pei J, Ni Z, et al. (2004). "Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L).". Exp. Cell Res. 298 (2): 329–38. doi:10.1016/j.yexcr.2004.04.031. PMID 15265683.
• Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.". Oncogene 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006.
• Takahashi Y, Miyoshi Y, Takahata C, et al. (2005). "Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.". Clin. Cancer Res. 11 (4): 1380–5. doi:10.1158/1078-0432.CCR-04-1773. PMID 15746036.
• Abe Y, Ohsugi M, Haraguchi K, et al. (2006). "LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis.". FEBS Lett. 580 (3): 782–8. doi:10.1016/j.febslet.2005.12.096. PMID 16413547.
• Voorhoeve PM, le Sage C, Schrier M, et al. (2006). "A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.". Cell 124 (6): 1169–81. doi:10.1016/j.cell.2006.02.037. PMID 16564011.
• Aylon Y, Michael D, Shmueli A, et al. (2007). "A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.". Genes Dev. 20 (19): 2687–700. doi:10.1101/gad.1447006. PMC 1578695. PMID 17015431.
• Jiang Z, Li X, Hu J, et al. (2007). "Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.". Neurosci. Res. 56 (4): 450–8. doi:10.1016/j.neures.2006.09.006. PMID 17049657.