AHCYL1

Adenosylhomocysteinase-like 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3MTG​
Identifiers
Symbols	AHCYL1 ; DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA
External IDs	OMIM: 607826 MGI: 2385184 HomoloGene: 77353 GeneCards: AHCYL1 Gene
EC number	3.3.1.1
Gene ontology Molecular function • RNA binding • adenosylhomocysteinase activity • protein binding Cellular component • cytoplasm • endoplasmic reticulum • cytosol • apical plasma membrane • extracellular exosome Biological process • mRNA polyadenylation • protein export from nucleus • one-carbon metabolic process • biological_process • positive regulation of sodium ion transport • regulation of mRNA 3'-end processing • regulation of ion transmembrane transporter activity • S-adenosylmethionine cycle • angiotensin-activated signaling pathway • regulation of anion transport • response to calcium ion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10768	229709
Ensembl	ENSG00000168710	ENSMUSG00000027893
UniProt	O43865	Q80SW1
RefSeq (mRNA)	NM_001242673	NM_145542
RefSeq (protein)	NP_001229602	NP_663517
Location (UCSC)	Chr 1: 109.98 – 110.02 Mb	Chr 3: 107.66 – 107.7 Mb
PubMed search

Putative adenosylhomocysteinase 2 is an enzyme that in humans is encoded by the AHCYL1 gene.^[1][2][3][4]

Interactions

AHCYL1 has been shown to interact with ITPR1.^[3]

References

1. Dekker JW, Budhia S, Angel NZ, Cooper BJ, Clark GJ, Hart DN, Kato M (Mar 2002). "Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation". Immunogenetics 53 (12): 993–1001. doi:10.1007/s00251-001-0402-z. PMID 11904675.
2. Cooper BJ, Key B, Carter A, Angel NZ, Hart DN, Kato M (Aug 2006). "Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling". J Biol Chem 281 (32): 22471–84. doi:10.1074/jbc.M602520200. PMID 16754674.
3. Ando H, Mizutani A, Matsu-ura T, Mikoshiba K (Mar 2003). "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". J Biol Chem 278 (12): 10602–12. doi:10.1074/jbc.M210119200. PMID 12525476.
4. "Entrez Gene: AHCYL1 S-adenosylhomocysteine hydrolase-like 1".

Further reading

• Pawlak A, Toussaint C, Lévy I; et al. (1995). "Characterization of a large population of mRNAs from human testis.". Genomics 26 (1): 151–8. doi:10.1016/0888-7543(95)80096-5. PMID 7782076.
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Cleaver JE, Afzal V, Feeney L; et al. (1999). "Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant.". Cancer Res. 59 (5): 1102–8. PMID 10070969.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Imabayashi H, Mori T, Gojo S; et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Y, Wolf-Yadlin A, Ross PL; et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Shirakabe K, Priori G, Yamada H; et al. (2006). "IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1).". Proc. Natl. Acad. Sci. U.S.A. 103 (25): 9542–7. doi:10.1073/pnas.0602250103. PMC 1480443. PMID 16769890.