HLA-DPB1

Major histocompatibility complex, class II, DP beta 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HLA-DPB1 ; DPB1; HLA-DP; HLA-DP1B; HLA-DPB
External IDs OMIM: 142858 HomoloGene: 129927 GeneCards: HLA-DPB1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3115 n/a
Ensembl ENSG00000215048 n/a
UniProt P04440 n/a
RefSeq (mRNA) NM_002121 n/a
RefSeq (protein) NP_002112 n/a
Location (UCSC) Chr 6:
33.08 – 33.09 Mb
n/a
PubMed search n/a

HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.[1]

See also

References

Further reading

This article is issued from Wikipedia - version of the Monday, July 27, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.