HLA-DPB1

Major histocompatibility complex, class II, DP beta 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3LQZ​, 4P4K​, 4P4R​, 4P57​
Identifiers
Symbols	HLA-DPB1 ; DPB1; HLA-DP; HLA-DP1B; HLA-DPB
External IDs	OMIM: 142858 HomoloGene: 129927 GeneCards: HLA-DPB1 Gene
Gene ontology Molecular function • peptide antigen binding Cellular component • Golgi membrane • lysosomal membrane • plasma membrane • cell surface • endosome membrane • ER to Golgi transport vesicle membrane • membrane • transport vesicle membrane • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane • trans-Golgi network membrane • MHC class II protein complex • integral component of lumenal side of endoplasmic reticulum membrane Biological process • cytokine-mediated signaling pathway • antigen processing and presentation of exogenous peptide antigen via MHC class II • T cell costimulation • positive regulation of interferon-gamma production • positive regulation of T cell proliferation • T cell receptor signaling pathway • positive regulation of T cell activation • interferon-gamma-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3115	n/a
Ensembl	ENSG00000215048	n/a
UniProt	P04440	n/a
RefSeq (mRNA)	NM_002121	n/a
RefSeq (protein)	NP_002112	n/a
Location (UCSC)	Chr 6: 33.08 – 33.09 Mb	n/a
PubMed search		n/a

HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.^[1]

See also

• Major histocompatibility complex
• Human leukocyte antigen
• HLA-DP

References

1. "Entrez Gene: HLA-DPB1 major histocompatibility complex, class II, DP beta 1".

Further reading

• Mitsunaga S, Kuwata S, Tokunaga K, et al. (1992). "Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles". Hum. Immunol. 34 (3): 203–11. doi:10.1016/0198-8859(92)90113-2. PMID 1358867.
• Marsh SG, Bodmer JG (1993). "HLA class II nucleotide sequences, 1992". Tissue Antigens 40 (5): 229–43. doi:10.1111/j.1399-0039.1992.tb02050.x. PMID 1362295.
• Eiermann TH, Uhl S, Fakler J, Goldmann SF (1992). "A novel HLA-DPB1 sequence, DPB1*2301". Tissue Antigens 40 (2): 108–10. doi:10.1111/j.1399-0039.1992.tb01969.x. PMID 1412416.
• Korioth F, Hartung K, Deicher H, Frey J (1992). "A new HLA-DPB1 allele from a patient with systemic lupus erythematosus". Tissue Antigens 39 (4): 216–9. doi:10.1111/j.1399-0039.1992.tb01938.x. PMID 1529429.
• de Koster HS, Kenter MJ, D'Amaro J, et al. (1991). "Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules". Immunogenetics 34 (1): 12–22. doi:10.1007/BF00212307. PMID 1713190.
• Vanderbeeken YE, Duchateau J, Colle H, et al. (1991). "Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated lymphocytes". Arch. Gynecol. Obstet. 248 (4): 199–209. doi:10.1007/BF02390359. PMID 1832848.
• Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305.
• Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. PMID 1967269.
• Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. doi:10.1073/pnas.87.22.9052. PMC 55099. PMID 1978941.
• Bugawan TL, Begovich AB, Erlich HA (1990). "Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes". Immunogenetics 32 (4): 231–41. doi:10.1007/BF00187094. PMID 2242906.
• Lair B, Alber C, Yu WY, et al. (1988). "A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity". J. Immunol. 141 (4): 1353–7. PMID 2456351.
• Bugawan TL, Horn GT, Long CM, et al. (1988). "Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci". J. Immunol. 141 (11): 4024–30. PMID 2460556.
• Begovich AB, Bugawan TL, Nepom BS, et al. (1990). "A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9489–93. doi:10.1073/pnas.86.23.9489. PMC 298522. PMID 2512583.
• Scholl P, Diez A, Mourad W, et al. (1989). "Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules". Proc. Natl. Acad. Sci. U.S.A. 86 (11): 4210–4. doi:10.1073/pnas.86.11.4210. PMC 287420. PMID 2542966.
• Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding". Nature 339 (6225): 548–51. doi:10.1038/339548a0. PMID 2543930.
• Lee JS, Sartoris S, Briata P, et al. (1989). "Sequence polymorphism of HLA-DP beta chains". Immunogenetics 29 (5): 346–9. doi:10.1007/BF00352845. PMID 2714855.
• Compagnone-Post P, Turco E, Robinson C, Trucco M (1988). "The beta-chains of DP4 molecules from different haplotypes are encoded by the same gene". Genomics 2 (1): 8–13. doi:10.1016/0888-7543(88)90103-6. PMID 2838415.
• Diamond DC, Sleckman BP, Gregory T, et al. (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. PMID 2846691.
• Ando A, Inoko H, Kimura M, et al. (1987). "Isolation and allelic polymorphism of cDNA clones and genomic clones of HLA-DP heavy and light chains". Hum. Immunol. 17 (3): 355–67. doi:10.1016/0198-8859(86)90286-7. PMID 2878910.
• Kelly A, Trowsdale J (1985). "Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes". Nucleic Acids Res. 13 (5): 1607–21. doi:10.1093/nar/13.5.1607. PMC 341099. PMID 2987832.