RIC8A

RIC8 guanine nucleotide exchange factor A
Identifiers
Symbols RIC8A ; RIC8
External IDs OMIM: 609146 MGI: 2141866 HomoloGene: 23331 GeneCards: RIC8A Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 60626 101489
Ensembl ENSG00000177963 ENSMUSG00000025485
UniProt Q9NPQ8 Q3TIR3
RefSeq (mRNA) NM_001286134 NM_053194
RefSeq (protein) NP_001273063 NP_444424
Location (UCSC) Chr 11:
0.21 – 0.22 Mb
Chr 7:
140.86 – 140.86 Mb
PubMed search

Synembryn-A is a protein that in humans is encoded by the RIC8A gene.[1][2][3]

Interactions

RIC8A has been shown to interact with GNAO1,[4] GNA13,[4] GNAQ,[4][5] GNAS complex locus,[5] GNAI2,[4] GNAI1[4] and GNAI3.[4]

References

  1. Miller KG, Emerson MD, McManus JR, Rand JB (Sep 2000). "RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system". Neuron 27 (2): 289–99. doi:10.1016/S0896-6273(00)00037-4. PMID 10985349.
  2. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  3. "Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)".
  4. 1 2 3 4 5 6 Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. (United States) 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430.
  5. 1 2 Klattenhoff, Carla; Montecino Martín; Soto Ximena; Guzmán Leonardo; Romo Ximena; García María Angeles; Mellstrom Britt; Naranjo José Ramón; Hinrichs María Victoria; Olate Juan (May 2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. (United States) 195 (2): 151–7. doi:10.1002/jcp.10300. ISSN 0021-9541. PMID 12652642.

Further reading


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