EPHB3

EPH receptor B3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3P1I​, 3ZFY​
Identifiers
Symbols	EPHB3 ; ETK2; HEK2; TYRO6
External IDs	OMIM: 601839 MGI: 104770 HomoloGene: 20938 ChEMBL: 4901 GeneCards: EPHB3 Gene
EC number	2.7.10.1
Gene ontology Molecular function • ephrin receptor activity • ATP binding • axon guidance receptor activity Cellular component • extracellular region • cytosol • plasma membrane • integral component of plasma membrane • dendrite Biological process • angiogenesis • urogenital system development • axon guidance • axonal fasciculation • cell migration • peptidyl-tyrosine phosphorylation • central nervous system projection neuron axonogenesis • corpus callosum development • regulation of cell-cell adhesion • retinal ganglion cell axon guidance • substrate adhesion-dependent cell spreading • regulation of GTPase activity • protein autophosphorylation • ephrin receptor signaling pathway • thymus development • digestive tract morphogenesis • regulation of axonogenesis • positive regulation of synapse assembly • palate development • dendritic spine development • dendritic spine morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2049	13845
Ensembl	ENSG00000182580	ENSMUSG00000005958
UniProt	P54753	P54754
RefSeq (mRNA)	NM_004443	NM_010143
RefSeq (protein)	NP_004434	NP_034273
Location (UCSC)	Chr 3: 184.56 – 184.58 Mb	Chr 16: 21.2 – 21.22 Mb
PubMed search

Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.^[1][2]

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.^[2]

Interactions

EPHB3 has been shown to interact with MLLT4^[3] and RAS p21 protein activator 1.^[4]

References

1. Böhme B, Holtrich U, Wolf G, Luzius H, Grzeschik KH, Strebhardt K, Rübsamen-Waigmann H (Oct 1993). "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2". Oncogene 8 (10): 2857–62. PMID 8397371.
2. "Entrez Gene: EPHB3 EPH receptor B3".
3. Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, Rübsamen-Waigmann H, Strebhardt K (Aug 1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
4. Hock B, Böhme B, Karn T, Feller S, Rübsamen-Waigmann H, Strebhardt K (Jul 1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions". Oncogene 17 (2): 255–60. doi:10.1038/sj.onc.1201907. PMID 9674711.

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
• Böhme B, VandenBos T, Cerretti DP, Park LS, Holtrich U, Rübsamen-Waigmann H, Strebhardt K (1996). "Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.". J. Biol. Chem. 271 (40): 24747–52. doi:10.1074/jbc.271.40.24747. PMID 8798744.
• Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
• Bergemann AD, Zhang L, Chiang MK, Brambilla R, Klein R, Flanagan JG (1998). "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube.". Oncogene 16 (4): 471–80. doi:10.1038/sj.onc.1201557. PMID 9484836.
• Hock B, Böhme B, Karn T, Feller S, Rübsamen-Waigmann H, Strebhardt K (1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.". Oncogene 17 (2): 255–60. doi:10.1038/sj.onc.1201907. PMID 9674711.
• Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, Rübsamen-Waigmann H, Strebhardt K (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
• Ciossek T, Monschau B, Kremoser C, Löschinger J, Lang S, Müller BK, Bonhoeffer F, Drescher U (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro.". Eur. J. Neurosci. 10 (5): 1574–80. doi:10.1046/j.1460-9568.1998.00180.x. PMID 9751130.
• Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R (1999). "Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.". Genes Dev. 13 (3): 295–306. doi:10.1101/gad.13.3.295. PMC 316426. PMID 9990854.