EPH receptor A5

EPH receptor A5
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2R2P​, 4ET7​
Identifiers
Symbols	EPHA5 ; CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4
External IDs	OMIM: 600004 MGI: 99654 HomoloGene: 55824 ChEMBL: 3987 GeneCards: EPHA5 Gene
EC number	2.7.10.1
Gene ontology Molecular function • ephrin receptor activity • GPI-linked ephrin receptor activity • transmembrane-ephrin receptor activity • ATP binding Cellular component • rough endoplasmic reticulum • plasma membrane • integral component of plasma membrane • external side of plasma membrane • axon • dendrite • neuronal cell body • perinuclear region of cytoplasm Biological process • axon guidance • peptidyl-tyrosine phosphorylation • cAMP-mediated signaling • hippocampus development • positive regulation of CREB transcription factor activity • regulation of actin cytoskeleton organization • regulation of GTPase activity • ephrin receptor signaling pathway • neuron development • regulation of insulin secretion involved in cellular response to glucose stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2044	13839
Ensembl	ENSG00000145242	ENSMUSG00000029245
UniProt	P54756	Q60629
RefSeq (mRNA)	NM_001281765	NM_007937
RefSeq (protein)	NP_001268694	NP_031963
Location (UCSC)	Chr 4: 65.32 – 65.67 Mb	Chr 5: 84.05 – 84.42 Mb
PubMed search

EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene.^[1][2][3]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.^[3]

References

1. Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
2. Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics 22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID 7528718.
3. "Entrez Gene: EPHA5 EPH receptor A5".

Further reading

• Zhou R (1997). "Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands.". Cell Tissue Res. 290 (2): 251–9. doi:10.1007/s004410050929. PMID 9321686.
• Caras IW (1997). "A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1.". Cell Tissue Res. 290 (2): 261–4. doi:10.1007/s004410050930. PMID 9321687.
• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
• Fox GM, Holst PL, Chute HT; et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.". Oncogene 10 (5): 897–905. PMID 7898931.
• Davis S, Gale NW, Aldrich TH; et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.". Science 266 (5186): 816–9. doi:10.1126/science.7973638. PMID 7973638.
• Gale NW, Holland SJ, Valenzuela DM; et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474.
• Miescher GC, Taylor V, Olivieri G; et al. (1997). "Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors.". Brain Res. Mol. Brain Res. 46 (1-2): 17–24. doi:10.1016/S0169-328X(96)00268-9. PMID 9191074.
• Stein E, Savaskan NE, Ninnemann O; et al. (1999). "A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting.". J. Neurosci. 19 (20): 8885–93. PMID 10516308.