RUFY1

RUN and FYVE domain containing 1
Rendering based on PDB 2YQM​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2YQM​, 2YW8​
Identifiers
Symbols	RUFY1 ; RABIP4; ZFYVE12
External IDs	OMIM: 610327 MGI: 2429762 HomoloGene: 23522 GeneCards: RUFY1 Gene
Gene ontology Molecular function • protein binding • zinc ion binding • lipid binding • protein transporter activity Cellular component • nucleus • cytoplasm • early endosome membrane • intracellular membrane-bounded organelle Biological process • endocytosis • protein transport • regulation of endocytosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80230	216724
Ensembl	ENSG00000176783	ENSMUSG00000020375
UniProt	Q96T51	Q8BIJ7
RefSeq (mRNA)	NM_001040451	NM_172557
RefSeq (protein)	NP_001035541	NP_766145
Location (UCSC)	Chr 5: 179.55 – 179.61 Mb	Chr 11: 50.39 – 50.43 Mb
PubMed search

RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the RUFY1 gene.^[1][2] It is named after the RUN and FYVE domains it contains.

Interactions

RUFY1 has been shown to interact with BMX.^[1]

References

1. Yang J, Kim O, Wu J, Qiu Y (Aug 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.
2. "Entrez Gene: RUFY1 RUN and FYVE domain containing 1".

Further reading

• Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand-Brustel Y (2001). "A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1637–42. doi:10.1073/pnas.031586998. PMC 29309. PMID 11172003.
• Fouraux MA, Deneka M, Ivan V, van der Heijden A, Raymackers J, van Suylekom D, van Venrooij WJ, van der Sluijs P, Pruijn GJ (2004). "Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes". Mol. Biol. Cell 15 (2): 611–24. doi:10.1091/mbc.E03-05-0343. PMC 329268. PMID 14617813.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.