Interleukin 1 receptor, type I

Interleukin 1 receptor, type I
PDB rendering based on 1g0y.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1G0Y​, 1IRA​, 1ITB​, 4DEP​, 4GAF​
Identifiers
Symbols	IL1R1 ; CD121A; D2S1473; IL-1R-alpha; IL1R; IL1RA; P80
External IDs	OMIM: 147810 MGI: 96545 HomoloGene: 677 ChEMBL: 1959 GeneCards: IL1R1 Gene
Gene ontology Molecular function • protease binding • signal transducer activity • transmembrane signaling receptor activity • interleukin-1 receptor activity • interleukin-1, Type I, activating receptor activity • platelet-derived growth factor receptor binding • protein binding • ionotropic glutamate receptor binding Cellular component • extracellular space • nucleus • plasma membrane • integral component of plasma membrane • cell surface • postsynaptic density • membrane • axon • protein complex Biological process • immune response • cell surface receptor signaling pathway • response to radiation • heat acclimation • ovulation • regulation of inflammatory response • interleukin-1-mediated signaling pathway • response to interleukin-1 • response to epidermal growth factor • cellular response to glucose stimulus • response to transforming growth factor beta • response to nitric oxide Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3554	16177
Ensembl	ENSG00000115594	ENSMUSG00000026072
UniProt	P14778	P13504
RefSeq (mRNA)	NM_000877	NM_001123382
RefSeq (protein)	NP_000868	NP_001116854
Location (UCSC)	Chr 2: 102.06 – 102.18 Mb	Chr 1: 40.23 – 40.32 Mb
PubMed search

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.^[1]

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.^[1]

Interactions

Interleukin 1 receptor, type I has been shown to interact with PIK3R1,^[2] Myd88^[3][4] and IL1RAP.^[5]

See also

• Cluster of differentiation
• Interleukin 1 receptor, type II

References

1. "Entrez Gene: IL1R1 interleukin 1 receptor, type I".
2. Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. (UNITED STATES) 272 (46): 29167–73. doi:10.1074/jbc.272.46.29167. ISSN 0021-9258. PMID 9360994.
3. Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. (ENGLAND) 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325.
4. Muzio, M; Ni J; Feng P; Dixit V M (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science (UNITED STATES) 278 (5343): 1612–5. doi:10.1126/science.278.5343.1612. ISSN 0036-8075. PMID 9374458.
5. Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (24): 12829–32. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.

Further reading

• Copeland NG, Silan CM, Kingsley DM, et al. (1991). "Chromosomal location of murine and human IL-1 receptor genes.". Genomics 9 (1): 44–50. doi:10.1016/0888-7543(91)90219-5. PMID 1672292.
• McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.". EMBO J. 10 (10): 2821–32. PMC 452992. PMID 1833184.
• Uhl J, Newton RC, Giri JG, et al. (1989). "Identification of IL-1 receptors on human monocytes.". J. Immunol. 142 (5): 1576–81. PMID 2521881.
• Sims JE, Acres RB, Grubin CE, et al. (1989). "Cloning the interleukin 1 receptor from human T cells.". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8946–50. doi:10.1073/pnas.86.22.8946. PMC 298407. PMID 2530587.
• Chua AO, Gubler U (1990). "Sequence of the cDNA for the human fibroblast type interleukin-1 receptor.". Nucleic Acids Res. 17 (23): 10114. doi:10.1093/nar/17.23.10114. PMC 335251. PMID 2532321.
• Dower SK, Kronheim SR, Hopp TP, et al. (1987). "The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical.". Nature 324 (6094): 266–8. doi:10.1038/324266a0. PMID 2946959.
• Rautonen N, Rautonen J, Martin NL, Wara DW (1995). "HIV-1 Tat induces cytokine synthesis by uninfected mononuclear cells.". AIDS 8 (10): 1504–6. doi:10.1097/00002030-199410000-00023. PMID 7818827.
• Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190–4. doi:10.1038/386190a0. PMID 9062193.
• Schreuder H, Tardif C, Trump-Kallmeyer S, et al. (1997). "A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist.". Nature 386 (6621): 194–200. doi:10.1038/386194a0. PMID 9062194.
• Rameshwar P, Poddar A, Zhu G, Gascón P (1997). "Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts.". J. Immunol. 158 (7): 3417–24. PMID 9120302.
• Reddy SA, Huang JH, Liao WS (1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation.". J. Biol. Chem. 272 (46): 29167–73. doi:10.1074/jbc.272.46.29167. PMID 9360994.
• Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. doi:10.1073/pnas.94.24.12829. PMC 24223. PMID 9371760.
• Muzio M, Ni J, Feng P, Dixit VM (1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.". Science 278 (5343): 1612–5. doi:10.1126/science.278.5343.1612. PMID 9374458.
• Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
• Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit.". Mol. Cell. Biol. 19 (7): 4798–805. PMC 84278. PMID 10373529.
• Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325.
• Vigers GP, Dripps DJ, Edwards CK, Brandhuber BJ (2001). "X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1.". J. Biol. Chem. 275 (47): 36927–33. doi:10.1074/jbc.M006071200. PMID 10903327.
• Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member.". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614.
• Joos L, McIntyre L, Ruan J, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863–6. doi:10.1136/thorax.56.11.863. PMC 1745962. PMID 11641511.
• Köller M, Kutscha-Lissberg F, Brom J, et al. (2003). "Influence of low molecular weight heparin (certoparin) and unfractionated heparin on the release of cytokines from human leukocytes.". Inflammation 25 (5): 331–7. doi:10.1023/A:1012883916991. PMID 11820460.

External links

• IL1R1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.