LILRA3
| Leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | LILRA3 ; CD85E; HM31; HM43; ILT-6; ILT6; LIR-4; LIR4 | ||||||||||||
| External IDs | OMIM: 604818 HomoloGene: 128752 GeneCards: LILRA3 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 11026 | n/a | |||||||||||
| Ensembl | ENSG00000273884 | n/a | |||||||||||
| UniProt | Q8N6C8 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001172654 | n/a | |||||||||||
| RefSeq (protein) | NP_001166125 | n/a | |||||||||||
| Location (UCSC) |
Chr CHR_HSCHR19LRC_COX1_CTG3_1: 54.29 – 54.31 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the eukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain. The function of LILRA3 is currently unknown. however it is highly homologous to other LILR genes,[1] and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.[2][3][4]
Like the closely related LILRA1, LILRA3 binds to both normal and 'unfolded' free heavy chains of HLA class I, with a preference for free heavy chains of HLA-C alleles [5]
See also
References
- ↑ Torkar M, Haude A, Milne S, Beck S, Trowsdale J,Wilson MJ (2000). "Arrangement of the ILT gene cluster: a common null allele of the LT6 gene results from a 6.7-kbp deletion". Eur J Immunol 30: 3655. doi:10.1002/1521-4141(200012)30:12<3655::aid-immu3655>3.0.co;2-y. PMID 1169408.
- ↑ Arm JP, Nwankwo C, Austen KF (Sep 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". J Immunol 159 (5): 2342–9. PMID 9278324.
- ↑ Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol 159 (11): 5192–6. PMID 9548455.
- ↑ "Entrez Gene: LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3".
- ↑ Jones DC, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, Chang C, Boyle LH, Taylor CJ, Trowsdale J, Allen RL (Mar 2011). "HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding". J Immunol 186 (5): 2990–7. doi:10.4049/jimmunol.1003078. PMID 21270408.
Further reading
- Samaridis J, Colonna M (1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways.". Eur. J. Immunol. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806.
- Cella M, Döhring C, Samaridis J, et al. (1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing.". J. Exp. Med. 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699.
- Colonna M, Navarro F, Bellón T, et al. (1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.". J. Exp. Med. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wiśniewski A, Łuszczek W, Mańczak M, et al. (2004). "Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls.". Hum. Immunol. 64 (4): 458–61. doi:10.1016/S0198-8859(03)00025-9. PMID 12651072.
- Norman PJ, Carey BS, Stephens HA, Vaughan RW (2003). "DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3.". Immunogenetics 55 (3): 165–71. doi:10.1007/s00251-003-0561-1. PMID 12750859.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
External links
- LILRA3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| ||||||||||||||||||||||||||||||
This article is issued from Wikipedia - version of the Tuesday, September 01, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.