KIR3DL1

Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3VH8, 3WUW

Identifiers

Symbols

KIR3DL1 ; CD158E1; KIR; KIR3DL1/S1; KIR3DL2; NKAT-3; NKAT3; NKB1; NKB1B

External IDs

OMIM: 604946 MGI: 3612791 HomoloGene: 135918 GeneCards: KIR3DL1 Gene

Gene ontology
Molecular function	• HLA-B specific inhibitory MHC class I receptor activity
Cellular component	• plasma membrane • integral component of plasma membrane
Biological process	• immune response • signal transduction • natural killer cell mediated cytotoxicity • regulation of immune response
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
54.72 – 54.87 Mb

Chr X:
131.8 – 131.82 Mb

PubMed search

Killer cell immunoglobulin-like receptor 3DL1 is a protein that in humans is encoded by the KIR3DL1 gene.^[1]^[2]^[3]

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte immunoglobulin-like receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.^[3]

References

↑ Colonna M, Samaridis J (May 1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". Science 268 (5209): 405–8. doi:10.1126/science.7716543. PMID 7716543.
↑ Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO (Jun 1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity 2 (5): 439–49. doi:10.1016/1074-7613(95)90025-X. PMID 7749980.
1 2 "Entrez Gene: KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1".

Selvakumar A, Steffens U, Dupont B (1997). "Polymorphism and domain variability of human killer cell inhibitory receptors.". Immunol. Rev. 155 (1): 183–96. doi:10.1111/j.1600-065X.1997.tb00951.x. PMID 9059894.
D'Andrea A, Chang C, Franz-Bacon K, et al. (1995). "Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.". J. Immunol. 155 (5): 2306–10. PMID 7650366.
Litwin V, Gumperz J, Parham P, et al. (1994). "NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules.". J. Exp. Med. 180 (2): 537–43. doi:10.1084/jem.180.2.537. PMC 2191610. PMID 8046332.
Döhring C, Samaridis J, Colonna M (1996). "Alternatively spliced forms of human killer inhibitory receptors.". Immunogenetics 44 (3): 227–30. doi:10.1007/BF02602590. PMID 8662091.
Pende D, Biassoni R, Cantoni C, et al. (1996). "The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.". J. Exp. Med. 184 (2): 505–18. doi:10.1084/jem.184.2.505. PMC 2192700. PMID 8760804.
Wagtmann N, Rajagopalan S, Winter CC, et al. (1996). "Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer.". Immunity 3 (6): 801–9. doi:10.1016/1074-7613(95)90069-1. PMID 8777725.
Valiante NM, Uhrberg M, Shilling HG, et al. (1998). "Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.". Immunity 7 (6): 739–51. doi:10.1016/S1074-7613(00)80393-3. PMID 9430220.
Uhrberg M, Valiante NM, Shum BP, et al. (1998). "Human diversity in killer cell inhibitory receptor genes.". Immunity 7 (6): 753–63. doi:10.1016/S1074-7613(00)80394-5. PMID 9430221.
Vyas Y, Selvakumar A, Steffens U, Dupont B (1999). "Multiple transcripts of the killer cell immunoglobulin-like receptor family, KIR3DL1 (NKB1), are expressed by natural killer cells of a single individual.". Tissue Antigens 52 (6): 510–9. doi:10.1111/j.1399-0039.1998.tb03081.x. PMID 9894849.
Kwon D, Chwae YJ, Choi IH, et al. (2000). "Diversity of the p70 killer cell inhibitory receptor (KIR3DL) family members in a single individual.". Mol. Cells 10 (1): 54–60. doi:10.1007/s10059-000-0054-0. PMID 10774747.
Crum KA, Logue SE, Curran MD, Middleton D (2001). "Development of a PCR-SSOP approach capable of defining the natural killer cell inhibitory receptor (KIR) gene sequence repertoires.". Tissue Antigens 56 (4): 313–26. doi:10.1034/j.1399-0039.2000.560403.x. PMID 11098931.
Gardiner CM, Guethlein LA, Shilling HG, et al. (2001). "Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism.". J. Immunol. 166 (5): 2992–3001. doi:10.4049/jimmunol.166.5.2992. PMID 11207248.
Yamochi T, Semba K, Tsuji K, et al. (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).". Eur. J. Biochem. 268 (23): 6076–82. doi:10.1046/j.0014-2956.2001.02555.x. PMID 11733001.
Shilling HG, Guethlein LA, Cheng NW, et al. (2002). "Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype.". J. Immunol. 168 (5): 2307–15. doi:10.4049/jimmunol.168.5.2307. PMID 11859120.
Martin MP, Gao X, Lee JH, et al. (2002). "Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS.". Nat. Genet. 31 (4): 429–34. doi:10.1038/ng934. PMID 12134147.
Chwae YJ, Chang MJ, Park SM, et al. (2002). "Molecular mechanism of the activation-induced cell death inhibition mediated by a p70 inhibitory killer cell Ig-like receptor in Jurkat T cells.". J. Immunol. 169 (7): 3726–35. doi:10.4049/jimmunol.169.7.3726. PMID 12244166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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KIR3DL1

See also

References

Further reading