CD109

CD109 molecule
Identifiers
Symbols	CD109 ; CPAMD7; p180; r150
External IDs	OMIM: 608859 MGI: 2445221 HomoloGene: 25183 GeneCards: CD109 Gene
Gene ontology Molecular function • serine-type endopeptidase inhibitor activity • transforming growth factor beta binding Cellular component • extracellular space • plasma membrane • cell surface • anchored component of membrane Biological process • negative regulation of protein phosphorylation • hair follicle development • negative regulation of keratinocyte proliferation • negative regulation of endopeptidase activity • negative regulation of transforming growth factor beta receptor signaling pathway • regulation of keratinocyte differentiation • negative regulation of wound healing • osteoclast fusion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	135228	235505
Ensembl	ENSG00000156535	ENSMUSG00000046186
UniProt	Q6YHK3	Q8R422
RefSeq (mRNA)	NM_001159587	NM_153098
RefSeq (protein)	NP_001153059	NP_694738
Location (UCSC)	Chr 6: 73.7 – 73.83 Mb	Chr 9: 78.62 – 78.72 Mb
PubMed search

CD109 (Cluster of Differentiation 109) is a human gene.^[1]

CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system, implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin et al., 2002).[supplied by OMIM]^[1]

See also

• Cluster of differentiation

References

1. "Entrez Gene: CD109 CD109 molecule".

Further reading

• Lucas GF, Metcalfe P (2000). "Platelet and granulocyte glycoprotein polymorphisms.". Transfusion medicine (Oxford, England) 10 (3): 157–74. doi:10.1046/j.1365-3148.2000.00250.x. PMID 10972910.
• Sutherland DR, Yeo E, Ryan A; et al. (1991). "Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets.". Blood 77 (1): 84–93. PMID 1984805.
• Kelton JG, Smith JW, Horsewood P; et al. (1990). "Gova/b alloantigen system on human platelets.". Blood 75 (11): 2172–6. PMID 2346781.
• Lin M, Sutherland DR, Horsfall W; et al. (2002). "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins.". Blood 99 (5): 1683–91. doi:10.1182/blood.V99.5.1683. PMID 11861284.
• Schuh AC, Watkins NA, Nguyen Q; et al. (2002). "A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens.". Blood 99 (5): 1692–8. doi:10.1182/blood.V99.5.1692. PMID 11861285.
• Giesert C, Marxer A, Sutherland DR; et al. (2003). "Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets.". Ann. N. Y. Acad. Sci. 996: 227–30. doi:10.1111/j.1749-6632.2003.tb03250.x. PMID 12799300.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Solomon KR, Sharma P, Chan M; et al. (2004). "CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family.". Gene 327 (2): 171–83. doi:10.1016/j.gene.2003.11.025. PMID 14980714.
• Zhang JM, Hashimoto M, Kawai K; et al. (2005). "CD109 expression in squamous cell carcinoma of the uterine cervix.". Pathol. Int. 55 (4): 165–9. doi:10.1111/j.1440-1827.2005.01807.x. PMID 15826242.
• Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.". Mol. Cell Proteomics 5 (2): 226–33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699.
• Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Finnson KW, Tam BY, Liu K; et al. (2006). "Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes". FASEB J. 20 (9): 1525–7. doi:10.1096/fj.05-5229fje. PMID 16754747.
• Sjöblom T, Jones S, Wood LD; et al. (2006). "The consensus coding sequences of human breast and colorectal cancers". Science 314 (5797): 268–74. doi:10.1126/science.1133427. PMID 16959974.
• Hasegawa M, Hagiwara S, Sato T; et al. (2007). "CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells". Pathol. Int. 57 (5): 245–50. doi:10.1111/j.1440-1827.2007.02097.x. PMID 17493171.

External links

• CD109 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)