CD200

CD200 molecule
Identifiers
Symbols	CD200 ; MOX1; MOX2; MRC; OX-2
External IDs	OMIM: 155970 MGI: 1196990 HomoloGene: 4344 GeneCards: CD200 Gene
Gene ontology Molecular function • receptor activity • receptor binding • protein binding • protein homodimerization activity • cell adhesion molecule binding Cellular component • plasma membrane • integral component of plasma membrane • cell-cell adherens junction Biological process • homophilic cell adhesion via plasma membrane adhesion molecules • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • cell recognition • regulation of immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4345	17470
Ensembl	ENSG00000091972	ENSMUSG00000022661
UniProt	P41217	O54901
RefSeq (mRNA)	NM_001004196	NM_010818
RefSeq (protein)	NP_001004196	NP_034948
Location (UCSC)	Chr 3: 112.33 – 112.36 Mb	Chr 16: 45.38 – 45.41 Mb
PubMed search

OX-2 membrane glycoprotein, also named CD200 (Cluster of Differentiation 200)^[1] is a human protein encoded by the CD200 gene.^[2]

The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.^[2]

See also

• Cluster of differentiation

References

1. "P41217 (OX2G_HUMAN)". Uniprot. Retrieved 16 May 2013.
2. "Entrez Gene: CD200 CD200 molecule".

Further reading

• Gorczynski RM (2002). "Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant rejection, fetal loss, autoimmunity and tumor growth". Arch. Immunol. Ther. Exp. (Warsz.) 49 (4): 303–9. PMID 11726033.
• Douglas J, Albertson DG, Barclay AN; et al. (1988). "RFLP and mapping of human MOX-1 gene on chromosome 3". Nucleic Acids Res. 16 (18): 9067. doi:10.1093/nar/16.18.9067. PMC 338677. PMID 2902568.
• McCaughan GW, Clark MJ, Barclay AN (1987). "Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein". Immunogenetics 25 (5): 329–35. doi:10.1007/BF00404426. PMID 3032785.
• Wright GJ, Puklavec MJ, Willis AC; et al. (2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID 10981966.
• Hoek RM, Ruuls SR, Murphy CA; et al. (2000). "Down-regulation of the macrophage lineage through interaction with OX2 (CD200)". Science 290 (5497): 1768–71. doi:10.1126/science.290.5497.1768. PMID 11099416.
• Wright GJ, Jones M, Puklavec MJ; et al. (2001). "The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans". Immunology 102 (2): 173–9. doi:10.1046/j.1365-2567.2001.01163.x. PMC 1783166. PMID 11260322.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wright GJ, Cherwinski H, Foster-Cuevas M; et al. (2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200". J. Immunol. 171 (6): 3034–46. doi:10.4049/jimmunol.171.6.3034. PMID 12960329.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chen DX, Gorczynski RM (2005). "Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function". Transplantation 79 (3): 282–8. doi:10.1097/01.TP.0000149506.61000.86. PMID 15699757.
• Chen Z, Marsden PA, Gorczynski RM (2006). "Cloning and characterization of the human CD200 promoter region". Mol. Immunol. 43 (6): 579–87. doi:10.1016/j.molimm.2005.04.014. PMID 15955564.
• Shiratori I, Yamaguchi M, Suzukawa M; et al. (2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200". J. Immunol. 175 (7): 4441–9. doi:10.4049/jimmunol.175.7.4441. PMID 16177086.
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Matsue H (2006). "CD 200-mediated regulation of skin immunity". J. Invest. Dermatol. 125 (6): x–xi. doi:10.1111/j.0022-202X.2005.23978.x. PMID 16354172.

External links

• CD200 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.