APRIL (protein)

Tumor necrosis factor (ligand) superfamily, member 13
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4ZCH​
Identifiers
Symbols	TNFSF13 ; APRIL; CD256; TALL-2; TALL2; TRDL-1; UNQ383/PRO715; ZTNF2
External IDs	OMIM: 604472 MGI: 1916833 HomoloGene: 56971 GeneCards: TNFSF13 Gene
Gene ontology Molecular function • receptor binding • cytokine activity • tumor necrosis factor receptor binding Cellular component • extracellular space • nucleoplasm • cytoplasm • cytosol • external side of plasma membrane • extracellular exosome Biological process • immunoglobulin production in mucosal tissue • positive regulation of germinal center formation • signal transduction • positive regulation of cell proliferation • gene expression • positive regulation of isotype switching to IgA isotypes Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8741	69583
Ensembl	ENSG00000161955	ENSMUSG00000089669
UniProt	O75888	Q9D777
RefSeq (mRNA)	NM_001198622	NM_001159505
RefSeq (protein)	NP_001185551	NP_001152977
Location (UCSC)	Chr 17: 7.56 – 7.56 Mb	Chr 11: 69.68 – 69.69 Mb
PubMed search

A proliferation-inducing ligand (APRIL), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI.^[1][2]

Nomenclature

In the cluster of differentiation terminology, APRIL is designated CD256.

Function

The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in April showed a reduced ability to support plasma cell survival In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.^[3]

Interactions

TNFSF13 has been shown to interact with TNFRSF13B^[4] and B-cell activating factor.^[5]

References

1. Hahne M, Kataoka T, Schröter M, Hofmann K, Irmler M, Bodmer JL, Schneider P, Bornand T, Holler N, French LE, Sordat B, Rimoldi D, Tschopp J (Sep 1998). "APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth". The Journal of Experimental Medicine 188 (6): 1185–90. doi:10.1084/jem.188.6.1185. PMC 2212534. PMID 9743536.
2. "Entrez Gene: TNFSF13 tumor necrosis factor (ligand) superfamily, member 13".
3. Belnoue E, Pihlgren M, McGaha TL, Tougne C, Rochat AF, Bossen C, Schneider P, Huard B, Lambert PH, Siegrist CA (Mar 2008). "APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells". Blood 111 (5): 2755–64. doi:10.1182/blood-2007-09-110858. PMID 18180376.
4. Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y, Cho YH, Garcia AD, Gollatz E, Dimke D, LaFleur D, Migone TS, Nardelli B, Wei P, Ruben SM, Ullrich SJ, Olsen HS, Kanakaraj P, Moore PA, Baker KP (Nov 2000). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". The Journal of Biological Chemistry 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646.
5. Roschke V, Sosnovtseva S, Ward CD, Hong JS, Smith R, Albert V, Stohl W, Baker KP, Ullrich S, Nardelli B, Hilbert DM, Migone TS (Oct 2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". Journal of Immunology 169 (8): 4314–21. doi:10.4049/jimmunol.169.8.4314. PMID 12370363.

Further reading

• Bossen C, Schneider P (Oct 2006). "BAFF, APRIL and their receptors: structure, function and signaling". Seminars in Immunology 18 (5): 263–75. doi:10.1016/j.smim.2006.04.006. PMID 16914324.
• Tangye SG, Bryant VL, Cuss AK, Good KL (Oct 2006). "BAFF, APRIL and human B cell disorders". Seminars in Immunology 18 (5): 305–17. doi:10.1016/j.smim.2006.04.004. PMID 16916610.
• Treml LS, Crowley JE, Cancro MP (Oct 2006). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells". Seminars in Immunology 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470.
• Mackay F, Leung H (Oct 2006). "The role of the BAFF/APRIL system on T cell function". Seminars in Immunology 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Shu HB, Hu WH, Johnson H (May 1999). "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens". Journal of Leukocyte Biology 65 (5): 680–3. PMID 10331498.
• Cousin P, Billotte J, Chaubert P, Shaw P (Jan 2000). "Physical map of 17p13 and the genes adjacent to p53". Genomics 63 (1): 60–8. doi:10.1006/geno.1999.6062. PMID 10662545.
• Kelly K, Manos E, Jensen G, Nadauld L, Jones DA (Feb 2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Research 60 (4): 1021–7. PMID 10706119.
• Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y, Cho YH, Garcia AD, Gollatz E, Dimke D, LaFleur D, Migone TS, Nardelli B, Wei P, Ruben SM, Ullrich SJ, Olsen HS, Kanakaraj P, Moore PA, Baker KP (Nov 2000). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". The Journal of Biological Chemistry 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646.
• Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M, McCabe S, Qiu WR, Kornuc M, Xia XZ, Guo J, Stolina M, Boyle WJ, Sarosi I, Hsu H, Senaldi G, Theill LE (Sep 2000). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nature Immunology 1 (3): 252–6. doi:10.1038/79802. PMID 10973284.
• Gallouzi IE, Brennan CM, Steitz JA (Sep 2001). "Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock". RNA 7 (9): 1348–61. doi:10.1017/S1355838201016089. PMC 1370177. PMID 11565755. (Retracted. If this is intentional, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
• López-Fraga M, Fernández R, Albar JP, Hahne M (Oct 2001). "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase". EMBO Reports 2 (10): 945–51. doi:10.1093/embo-reports/kve198. PMC 1084076. PMID 11571266.
• Stein JV, López-Fraga M, Elustondo FA, Carvalho-Pinto CE, Rodríguez D, Gómez-Caro R, De Jong J, Martínez-A C, Medema JP, Hahne M (Jun 2002). "APRIL modulates B and T cell immunity". The Journal of Clinical Investigation 109 (12): 1587–98. doi:10.1172/JCI15034. PMC 151011. PMID 12070306.
• Litinskiy MB, Nardelli B, Hilbert DM, He B, Schaffer A, Casali P, Cerutti A (Sep 2002). "DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL". Nature Immunology 3 (9): 822–9. doi:10.1038/ni829. PMID 12154359.
• Roschke V, Sosnovtseva S, Ward CD, Hong JS, Smith R, Albert V, Stohl W, Baker KP, Ullrich S, Nardelli B, Hilbert DM, Migone TS (Oct 2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". Journal of Immunology 169 (8): 4314–21. doi:10.4049/jimmunol.169.8.4314. PMID 12370363.
• Pradet-Balade B, Medema JP, López-Fraga M, Lozano JC, Kolfschoten GM, Picard A, Martínez-A C, Garcia-Sanz JA, Hahne M (Nov 2002). "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein". The EMBO Journal 21 (21): 5711–20. doi:10.1093/emboj/cdf565. PMC 131062. PMID 12411489.

External links

• TNFSF13 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.