CD276

CD276 molecule
Identifiers
Symbols	CD276 ; 4Ig-B7-H3; B7-H3; B7H3; B7RP-2
External IDs	OMIM: 605715 MGI: 2183926 HomoloGene: 11892 GeneCards: CD276 Gene
Gene ontology Molecular function • receptor binding • protein binding Cellular component • external side of plasma membrane • integral component of membrane • extracellular exosome Biological process • immune response • cell proliferation • positive regulation of bone mineralization • positive regulation of T cell proliferation • T cell activation • negative regulation of T cell proliferation • negative regulation of interferon-gamma biosynthetic process • positive regulation of interferon-gamma biosynthetic process • negative regulation of interleukin-2 biosynthetic process • positive regulation of osteoblast differentiation • negative regulation of inflammatory response • regulation of immune response • positive regulation of interleukin-2 secretion Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80381	102657
Ensembl	ENSG00000103855	ENSMUSG00000035914
UniProt	Q5ZPR3	Q8VE98
RefSeq (mRNA)	NM_001024736	NM_133983
RefSeq (protein)	NP_001019907	NP_598744
Location (UCSC)	Chr 15: 73.68 – 73.71 Mb	Chr 9: 58.52 – 58.56 Mb
PubMed search

CD276 (Cluster of Differentiation 276) is a human protein encoded by the CD276 gene.^[1]

Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).[supplied by OMIM]^[1]

CD276 (aka B7-H3), an immune checkpoint molecule, is expressed by some solid tumours and is the target of anticancer candidates such as MGA271.^[2]

See also

• Cluster of differentiation

References

1. "Entrez Gene: CD276 CD276 molecule".
2. http://www.genengnews.com/gen-news-highlights/servier-pays-macrogenics-20m-for-option-to-anticancer-antibody/81246017/

Further reading

• Chapoval AI, Ni J, Lau JS; et al. (2001). "B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production". Nat. Immunol. 2 (3): 269–74. doi:10.1038/85339. PMID 11224528.
• Sun M, Richards S, Prasad DV; et al. (2002). "Characterization of mouse and human B7-H3 genes". J. Immunol. 168 (12): 6294–7. doi:10.4049/jimmunol.168.12.6294. PMID 12055244.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ling V, Wu PW, Spaulding V; et al. (2004). "Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss". Genomics 82 (3): 365–77. doi:10.1016/S0888-7543(03)00126-5. PMID 12906861.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Steinberger P, Majdic O, Derdak SV; et al. (2004). "Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains". J. Immunol. 172 (4): 2352–9. doi:10.4049/jimmunol.172.4.2352. PMID 14764704.
• Zhang GB, Chen YJ, Shi Q; et al. (2005). "Human recombinant B7-H3 expressed in E. coli enhances T lymphocyte proliferation and IL-10 secretion in vitro". Acta Biochim. Biophys. Sin. (Shanghai) 36 (6): 430–6. doi:10.1093/abbs/36.6.430. PMID 15188059.
• Castriconi R, Dondero A, Augugliaro R; et al. (2004). "Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis". Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12640–5. doi:10.1073/pnas.0405025101. PMC 515110. PMID 15314238.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang L, Fraser CC, Kikly K; et al. (2005). "B7-H3 promotes acute and chronic allograft rejection". Eur. J. Immunol. 35 (2): 428–38. doi:10.1002/eji.200425518. PMID 15682454.
• Kim J, Myers AC, Chen L; et al. (2005). "Constitutive and Inducible Expression of B7 Family of Ligands by Human Airway Epithelial Cells". Am. J. Respir. Cell Mol. Biol. 33 (3): 280–9. doi:10.1165/rcmb.2004-0129OC. PMC 2715317. PMID 15961727.
• Petroff MG, Kharatyan E, Torry DS, Holets L (2005). "The Immunomodulatory Proteins B7-DC, B7-H2, and B7-H3 Are Differentially Expressed across Gestation in the Human Placenta". Am. J. Pathol. 167 (2): 465–73. doi:10.1016/S0002-9440(10)62990-2. PMC 1603571. PMID 16049332.
• Zhang GB, Dong QM, Xu Y; et al. (2005). "B7-H3: Another Molecule Marker for Mo-DCs?". Cell. Mol. Immunol. 2 (4): 307–11. PMID 16274630.
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Sakthivel P, Wang X, Gharizadeh B; et al. (2007). "Single-nucleotide polymorphisms in the B7H3 gene are not associated with human autoimmune myasthenia gravis". J. Genet. 85 (3): 217–20. doi:10.1007/BF02935335. PMID 17406098.

External links

• CD276 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)