Tumor necrosis factor receptor 2

Tumor necrosis factor receptor superfamily, member 1B
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1CA9​, 3ALQ​
Identifiers
Symbols	TNFRSF1B ; CD120b; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80; p75; p75TNFR
External IDs	OMIM: 191191 MGI: 1314883 HomoloGene: 829 ChEMBL: 1250356 GeneCards: TNFRSF1B Gene
Gene ontology Molecular function • tumor necrosis factor-activated receptor activity • protein binding • ubiquitin protein ligase binding Cellular component • extracellular region • nucleus • plasma membrane • integral component of membrane • neuronal cell body • varicosity • membrane raft • perinuclear region of cytoplasm Biological process • inflammatory response • immune response • aging • intrinsic apoptotic signaling pathway in response to DNA damage • tumor necrosis factor-mediated signaling pathway • negative regulation of inflammatory response • RNA destabilization • positive regulation of membrane protein ectodomain proteolysis • cellular response to lipopolysaccharide • cellular response to growth factor stimulus • extrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7133	21938
Ensembl	ENSG00000028137	ENSMUSG00000028599
UniProt	P20333	P25119
RefSeq (mRNA)	NM_001066	NM_011610
RefSeq (protein)	NP_001057	NP_035740
Location (UCSC)	Chr 1: 12.17 – 12.21 Mb	Chr 4: 145.21 – 145.25 Mb
PubMed search

Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and CD120b, is a membrane receptor that binds tumor necrosis factor-alpha (TNFα).^[1][2]

Function

The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2 (TRAF2), which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.^[3]

Interactions

TNFRSF1B has been shown to interact with:

• TRAF2,^{[4][5][6][7][8][9][10]} and
• TTRAP.^[11]

References

1. Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GH, Gatanaga T, Granger GA, Lentz R, Raab H, et al. (June 1990). "Molecular cloning and expression of a receptor for human tumor necrosis factor". Cell 61 (2): 361–70. doi:10.1016/0092-8674(90)90816-W. PMID 2158863.
2. Santee SM, Owen-Schaub LB (October 1996). "Human tumor necrosis factor receptor p75/80 (CD120b) gene structure and promoter characterization". J Biol Chem 271 (35): 21151–9. doi:10.1074/jbc.271.35.21151. PMID 8702885.
3. 7133 "Entrez Gene: TNFRSF1B tumor necrosis factor receptor superfamily, member 1B" Check |url= value (help).
4. Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
5. Song HY, Donner DB (1995). "Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor". Biochem. J. 309 (3): 825–9. PMC 1135706. PMID 7639698.
6. Takeuchi M, Rothe M, Goeddel DV (1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. 271 (33): 19935–42. doi:10.1074/jbc.271.33.19935. PMID 8702708.
7. Hostager BS, Bishop GA (2002). "Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b". J. Immunol. 168 (7): 3318–22. doi:10.4049/jimmunol.168.7.3318. PMID 11907088.
8. Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. PMC 38654. PMID 8710854.
9. Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. PMID 9162022.
10. Carpentier I, Coornaert B, Beyaert R (2008). "Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation". Biochem. Biophys. Res. Commun. 374 (4): 752–7. doi:10.1016/j.bbrc.2008.07.103. PMID 18671942.
11. Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE (2000). "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. doi:10.1074/jbc.M000531200. PMID 10764746.

Further reading

• Kollias G, Kontoyiannis D (2003). "Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments.". Cytokine Growth Factor Rev. 13 (4–5): 315–21. doi:10.1016/S1359-6101(02)00019-9. PMID 12220546.
• Holtmann MH, Schuchmann M, Zeller G, et al. (2003). "The emerging distinct role of TNF-receptor 2 (p80) signaling in chronic inflammatory disorders". Arch. Immunol. Ther. Exp. (Warsz.) 50 (4): 279–88. PMID 12371624.
• Horiuchi T, Kiyohara C, Tsukamoto H, et al. (2007). "A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis". Ann. Rheum. Dis. 66 (3): 320–4. doi:10.1136/ard.2006.058917. PMC 1856025. PMID 17028114.

External links

• CD120b Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)