TTRAP

Tyrosyl-DNA phosphodiesterase 2
Identifiers
Symbols	TDP2 ; AD022; EAP2; EAPII; TTRAP; dJ30M3.3; hTDP2
External IDs	OMIM: 605764 MGI: 1860486 HomoloGene: 9591 GeneCards: TDP2 Gene
EC number	3.1.4.-
Gene ontology Molecular function • magnesium ion binding • single-stranded DNA binding • transcription corepressor activity • nuclease activity • protein binding • manganese ion binding • tyrosyl-RNA phosphodiesterase activity • 5'-tyrosyl-DNA phosphodiesterase activity Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • PML body • intercellular bridge Biological process • double-strand break repair • cell surface receptor signaling pathway • nucleic acid phosphodiester bond hydrolysis • negative regulation of nucleic acid-templated transcription Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51567	56196
Ensembl	ENSG00000111802	ENSMUSG00000035958
UniProt	O95551	Q9JJX7
RefSeq (mRNA)	NM_016614	NM_019551
RefSeq (protein)	NP_057698	NP_062424
Location (UCSC)	Chr 6: 24.65 – 24.67 Mb	Chr 13: 24.83 – 24.84 Mb
PubMed search

TRAF and TNF receptor-associated protein is a protein that in humans is encoded by the TTRAP gene.^[1][2]

Function

This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.^[2]

Interactions

TTRAP has been shown to interact with ETS1,^[3] TNFRSF1B^[4] and CD40.^[4]

References

1. Rodrigues-Lima F, Josephs M, Katan M, Cassinat B (July 2001). "Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases". Biochem. Biophys. Res. Commun. 285 (5): 1274–9. doi:10.1006/bbrc.2001.5328. PMID 11478795.
2. "Entrez Gene: TTRAP TRAF and TNF receptor associated protein".
3. Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R (May 2003). "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene 22 (18): 2699–709. doi:10.1038/sj.onc.1206374. PMID 12743594.
4. Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE (June 2000). "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. doi:10.1074/jbc.M000531200. PMID 10764746.

Further reading

• Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE (2000). "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. doi:10.1074/jbc.M000531200. PMID 10764746.
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R (2003). "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene 22 (18): 2699–709. doi:10.1038/sj.onc.1206374. PMID 12743594.
• Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J (2003). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Luciano M, Lind PA, Duffy DL, Castles A, Wright MJ, Montgomery GW, Martin NG, Bates TC (2007). "A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability". Biol. Psychiatry 62 (7): 811–7. doi:10.1016/j.biopsych.2007.03.007. PMID 17597587.