CEACAM3

Carcinoembryonic antigen-related cell adhesion molecule 3
Identifiers
Symbols	CEACAM3 ; CD66D; CEA; CGM1; W264; W282
External IDs	OMIM: 609142 MGI: 1347248 HomoloGene: 130497 GeneCards: CEACAM3 Gene
Gene ontology Cellular component • integral component of membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1084	26366
Ensembl	ENSG00000170956	ENSMUSG00000054169
UniProt	P40198	Q61400
RefSeq (mRNA)	NM_001277163	NM_007675
RefSeq (protein)	NP_001264092	NP_031701
Location (UCSC)	Chr 19: 41.8 – 41.81 Mb	Chr 7: 24.49 – 24.49 Mb
PubMed search

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d (Cluster of Differentiation 66d), is a human gene.^[1]

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[1]

Use

CEACAM3 is expressed exclusively on granulocytes and used as granulocyte marker.^[2]

See also

• Cluster of differentiation

References

1. "Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3".
2. CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens. Pils S, Gerrard DT, Meyer A, Hauck CR. Int J Med Microbiol. 2008 Oct;298(7-8):553-60.

Further reading

• Khan WN, Frängsmyr L, Teglund S; et al. (1992). "Identification of three new genes and estimation of the size of the carcinoembryonic antigen family". Genomics 14 (2): 384–90. doi:10.1016/S0888-7543(05)80230-7. PMID 1427854.
• Kuroki M, Arakawa F, Matsuo Y; et al. (1991). "Molecular cloning of nonspecific cross-reacting antigens in human granulocytes". J. Biol. Chem. 266 (18): 11810–7. PMID 2050678.
• Thompson JA, Mauch EM, Chen FS; et al. (1989). "Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons". Biochem. Biophys. Res. Commun. 158 (3): 996–1004. doi:10.1016/0006-291X(89)92821-0. PMID 2537643.
• Watt SM, Fawcett J, Murdoch SJ; et al. (1994). "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant". Blood 84 (1): 200–10. PMID 8018919.
• Nagel G, Grunert F, Kuijpers TW; et al. (1993). "Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family". Eur. J. Biochem. 214 (1): 27–35. doi:10.1111/j.1432-1033.1993.tb17892.x. PMID 8508798.
• Skubitz KM, Campbell KD, Skubitz AP (1996). "CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils". J. Leukoc. Biol. 60 (1): 106–17. PMID 8699114.
• Streichert T, Ebrahimnejad A, Ganzer S; et al. (2001). "The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes". Biochem. Biophys. Res. Commun. 289 (1): 191–7. doi:10.1006/bbrc.2001.5955. PMID 11708798.
• Skubitz KM, Campbell KD, Skubitz AP (2002). "Synthetic peptides from the N-domains of CEACAMs activate neutrophils". J. Pept. Res. 58 (6): 515–26. doi:10.1034/j.1399-3011.2001.00931.x. PMID 12005421.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Booth JW, Telio D, Liao EH; et al. (2003). "Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae". J. Biol. Chem. 278 (16): 14037–45. doi:10.1074/jbc.M211879200. PMID 12571236.
• McCaw SE, Schneider J, Liao EH; et al. (2003). "Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor". Mol. Microbiol. 49 (3): 623–37. doi:10.1046/j.1365-2958.2003.03591.x. PMID 12864848.
• Schmitter T, Agerer F, Peterson L; et al. (2004). "Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens". J. Exp. Med. 199 (1): 35–46. doi:10.1084/jem.20030204. PMC 1887732. PMID 14707113.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gimbergues P, Dauplat MM, Cayre A; et al. (2007). "Correlation between molecular metastases in sentinel lymph nodes of breast cancer patients and St Gallen risk category". Eur J Surg Oncol 33 (1): 16–22. doi:10.1016/j.ejso.2006.09.013. PMID 17071045.
• Gasser M, Gerstlauer C, Grimm M; et al. (2007). "Comparative analysis of predictive biomarkers for therapeutical strategies in colorectal cancer". Ann. Surg. Oncol. 14 (4): 1272–84. doi:10.1245/s10434-006-9155-0. PMID 17211733.
• Howell NR, Zheng W, Cheng L; et al. (2007). "Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis?". Int. J. Gynecol. Pathol. 26 (2): 134–40. doi:10.1097/01.pgp.0000233166.56385.d0. PMID 17413979.
• Stern-Ginossar N, Nedvetzki S, Markel G; et al. (2007). "Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells". J. Immunol. 179 (7): 4424–34. doi:10.4049/jimmunol.179.7.4424. PMID 17878338.

External links

• CEACAM3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.